USA300-related methicillin-resistant Staphylococcus aureus clone is the predominant cause of community and hospital MRSA infections in Colombian children

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dc.contributor.authorMarquez-Ortiz, Ricaurte Alejandro
dc.contributor.authorÁlvarez-Olmos, Martha I.
dc.contributor.authorEscobar-Pérez, Javier
dc.contributor.authorLeal, Aura Lucia
dc.contributor.authorCastro Cardozo, Betsy Esperanza
dc.contributor.authorMariño, Ana Cristina
dc.contributor.authorBarrero, Esther Rocio
dc.contributor.authorMujica, Sandra Celina
dc.contributor.authorGaines, Sebastian
dc.contributor.authorVanegas, Natasha
dc.contributor.orcidEscobar-Pérez, Javier [0000-0002-0432-6978]
dc.date.accessioned2020-05-12T21:20:34Z
dc.date.available2020-05-12T21:20:34Z
dc.date.issued2014
dc.description.abstractenglishObjective Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) isolates are known to be more virulent and clinically aggressive in children. The goal of the present study was characterize the molecular epidemiology of MRSA isolates causing infections in Colombian children. Methods An observational and prospective study was conducted between April 2009 and June 2011 at 15 hospitals in Bogotá, Colombia. A detailed epidemiological profile was made of 162 children infected with MRSA. The isolates were subjected to antimicrobial susceptibility testing, molecular characterization including 21 virulence genes, SCCmec, spa and agr typing, multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). Results Among all isolates included in the study, 85.8% were obtained from patients whose infectious process was initiated in the community; of these, 69,8% occurred in patients without healthcare-associated risk factors. The molecular characterization of the isolates showed a high proportion (95.1%) containing a community-genotype profile with a high prevalence of SCCmec type IV, PVL-positives, and also related to CC8. Most CG-MRSA isolates (143, 92.9%) were genetically related to the pandemic clone USA300, differing by the presence of SCCmec IVc and the absence of the arginine catabolic mobile element (ACME). Conclusions An increase in the frequency of CG-MRSA infections has been reported worldwide. In this study we found that almost all MRSA infections in our pediatric population were caused by community-genotype isolates, supporting the success of the CG-MRSA clones.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2014.01.008
dc.identifier.issn1201-9712
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2648
dc.language.isoeng
dc.publisherElsevier BVspa
dc.publisher.journalInternational Journal of Infectious Diseasesspa
dc.relation.ispartofseriesInternational Journal of Infectious Diseases, 1201-9712, Vol.25, 2014, p.88-93spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1201971214000447
dc.rights.creativecommons2014
dc.rights.localAcceso cerradospa
dc.subject.decsStaphylococcus aureusspa
dc.subject.decsEpidemiología molecularspa
dc.subject.decsArgininaspa
dc.subject.keywordsChildrenspa
dc.subject.keywordsCO-MRSAspa
dc.subject.keywordsUSA300spa
dc.subject.keywordsCG-MRSAspa
dc.subject.keywordsClonal replacementspa
dc.subject.keywordsColombiaspa
dc.titleUSA300-related methicillin-resistant Staphylococcus aureus clone is the predominant cause of community and hospital MRSA infections in Colombian childrenspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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