Predictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical region

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dc.contributor.authorRodríguez, Diego Andrés
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.contributor.authorCárdenas, Andrea Constanza
dc.contributor.authorQuilaguy, Ivonne Emilce
dc.contributor.authorMayorga, Leydy Yasmin
dc.contributor.authorFalla, Luz Marlesvy
dc.contributor.authorNiño, Gustavo
dc.date.accessioned2020-07-13T21:21:26Z
dc.date.available2020-07-13T21:21:26Z
dc.date.issued2014
dc.description.abstractenglishRespiratory syncytial virus (RSV) is one of the leading causes of acute lower respiratory infection (ALRI) in infants and young children. Although ALRI is a major public health problem in developing countries located in tropical areas, studies about RSV epidemiology in these regions are scarce. In a retrospective cohort study, we investigated the epidemiology and predictive variables that reflect disease severity and mortality in young children hospitalized with ALRI due to RSV in Colombia, South-America, during a 2-year period (2009–2011). Of a total of 6,344 children with a diagnosis of ALRI, we selected 2,147 (33.8%) that were positive for RSV. After controlling for pre-existing conditions, we found that independent predictors of severe disease in our population included age <6 months (RR 2.01; CI 95% 1.70–2.38; P < 0.001), prematurity (RR 1.61; CI 95% 1.20–2.17; P = 0.001), congenital heart disease (RR 2.03; CI 95% 1.16–3.54; P = 0.013), and mixed RSV-adenovirus infection (RR 2.09; CI 95% 1.60–2.73; P < 0.001). Multivariate analysis identified that cancer (RR 31.60; CI 95% 5.97–167.13; P < 0.001) is a predictor of mortality in our RSV-infected pediatric population independently of age and other co-morbidities. RSV is an important cause of ALRI in infants and young children living in tropical regions, especially during the rainy season. The identified predictors of severe disease and mortality should be taken into account when planning interventions to reduce the burden of ALRI in young children living in these regions.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/ppul.22781
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1099-0496
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3480
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalPediatric Pulmonologyspa
dc.relation.ispartofseriesPediatric Pulmonology, 1099-0496, Vol. 49, Nro. 3, 2014, p. 269 – 276spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/ppul.22781
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2013-03
dc.rights.localAcceso abiertospa
dc.subject.keywordsRespiratory syncytial virusspa
dc.subject.keywordsAcute respiratory infectionspa
dc.subject.keywordsPediatricsspa
dc.titlePredictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical regionspa
dc.title.translatedPredictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical regionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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