Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase

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dc.contributor.authorArias, Cesar A.
dc.contributor.authorVallejo, Martha
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorPanesso, Diana
dc.contributor.authorMoreno, Jaime
dc.contributor.authorCastañeda, Elizabeth
dc.contributor.authorVillegas, María Virginia
dc.contributor.authorMurray, Barbara E.
dc.contributor.authorQuinn, John P.
dc.contributor.orcidPanesso, Diana [0000-0002-4049-9702]
dc.contributor.orcidVillegas, María Virginia [0000-0003-1898-9067]
dc.date.accessioned2020-08-31T09:40:01Z
dc.date.available2020-08-31T09:40:01Z
dc.date.issued2008
dc.description.abstractenglishThe cfr (chloramphenicol-florfenicol resistance) gene encodes a 23S rRNA methyltransferase that confers resistance to linezolid. Detection of linezolid resistance was evaluated in the first cfr-carrying human hospital isolate of linezolid and methicillin-resistant Staphylococcus aureus (designated MRSA CM-05) by dilution and diffusion methods (including Etest). The presence of cfr was investigated in isolates of staphylococci colonizing the patient's household contacts and clinical isolates recovered from patients in the same unit where MRSA CM-05 was isolated. Additionally, 68 chloramphenicol-resistant Colombian MRSA isolates recovered from hospitals between 2001 and 2004 were screened for the presence of the cfr gene. In addition to erm(B), the erm(A) gene was also detected in CM-05. The isolate belonged to sequence type 5 and carried staphylococcal chromosomal cassette mec type I. We were unable to detect the cfr gene in any of the human staphylococci screened (either clinical or colonizing isolates). Agar and broth dilution methods detected linezolid resistance in CM-05. However, the Etest and disk diffusion methods failed to detect resistance after 24 h of incubation. Oxazolidinone resistance mediated by the cfr gene is rare, and acquisition by a human isolate appears to be a recent event in Colombia. The detection of cfr-mediated linezolid resistance might be compromised by the use of the disk diffusion or Etest method.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1128%2FJCM.01886-07
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-660X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3883
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalJournal of Clinical Microbiologyspa
dc.relation.ispartofseriesJournal of Clinical Microbiology, 1098-660X, Vol. 46, Nro. 3, 2008 p. 892-896spa
dc.relation.urihttps://jcm.asm.org/content/46/3/892
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2008-03
dc.rights.localAcceso abiertospa
dc.subject.decsAcetamidasspa
dc.subject.decsMetiltransferasasspa
dc.subject.decsTransferasas del grupo 1-carbonospa
dc.titleClinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferasespa
dc.title.translatedClinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferasespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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