Low-cost devices to prevent SARS-CoV-2 infection during open and laparoscopic surgery

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dc.contributor.authorCabrera Vargas, Luis Felipe
dc.contributor.authorTorregrosa Almonacid, Lilian
dc.contributor.authorGuevara, Óscar Alexander
dc.contributor.authorPedraza Ciro, Mauricio
dc.contributor.authorCarrera, Javier A.
dc.contributor.authorVillarreal, Ricardo A.
dc.contributor.authorVinck, Erick
dc.contributor.authorCabrera, Laura
dc.contributor.authorFerrada, Paula
dc.contributor.authorChen, Herbert
dc.contributor.orcidPedraza Ciro, Mauricio [0000-0001-8726-5578]
dc.date.accessioned2020-08-10T20:22:07Z
dc.date.available2020-08-10T20:22:07Z
dc.date.issued2020
dc.description.abstractenglishObjective To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals. Materials and methods Fifty-one patients with a diagnosis of eRA and 51 healthy controls matched for age and sex were studied. Clinical joint condition, clinical and serological markers of disease activity, serum adipokine levels (leptin, adiponectin, resistin, adipsin, vaspin, and IL-6), periodontal diagnosis, presence of Porphyromonas gingivalis, and related IgG1 and IgG2 antibodies were evaluated. Comparisons were made between eRA and healthy controls for periodontal indicators and adipokines. A subgroup analysis was realized with a non-conditional logistic regression to establish the association between the levels of leptin in individuals with eRA and controls according to the periodontal condition, presence of P. gingivalis, or high titers of IgG antibodies against P. gingivalis. Results The condition of overweight or obesity is associated with the diagnosis of eRA (p = 0.05), and these individuals also have higher levels of leptin (p = 0.001) and vaspin (p = 0.007). Higher frequency of P. gingivalis (p = 0.001) was found in the eRa group. Individuals with eRA with higher IgG2 titers against P. gingivalis had higher levels of leptin (OR: 1.66 (CI 95% 1.01–2.73)); however, individuals with periodontitis or P. gingivalis with eRA were associated with highest levels of leptin (OR: 1.86, CI 95% 1.19–24.3; and OR: 2.04, CI 95% 1.37–3 respectively). Conclusions eRA individuals have high levels of leptin and vaspin. However, the presence of periodontitis and related-periodontal disease markers showed an effect only in leptin levels in eRA individuals. Clinical relevance Emphasizing in personalized medicine, monitoring serum leptin levels and periodontitis markers can improve the early diagnosis of RA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.amjsurg.2020.07.014
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1879-1883
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3748
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalClinical oral investigationsspa
dc.publisher.journalAmerican journal of surgeryspa
dc.relation.ispartofseriesAmerican journal of surgery, 1879-1883, 2020spa
dc.relation.urihttps://www.americanjournalofsurgery.com/article/S0002-9610(20)30443-8/fulltext
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-07-22
dc.rights.localAcceso abiertospa
dc.subject.keywordsSurgical smokespa
dc.subject.keywordsAerosolspa
dc.subject.keywordsFilterspa
dc.subject.keywordsCOVID-19spa
dc.titleLow-cost devices to prevent SARS-CoV-2 infection during open and laparoscopic surgeryspa
dc.title.translatedLow-cost devices to prevent SARS-CoV-2 infection during open and laparoscopic surgeryspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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