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dc.contributor.authorDuran Cristiano, Sandra Carolina
dc.contributor.authorGómez-Molina, Andrea
dc.contributor.orcidDuran Cristiano, Sandra Carolina[0000-0002-5366-8552]
dc.date.accessioned2021-05-06T13:47:10Z
dc.date.available2021-05-06T13:47:10Z
dc.date.issued2020-07-22
dc.description.abstractEl fluido lagrimal se caracteriza por ser una mezcla de moléculas que incluye proteínas, lípidos, metabolitos, entre otros; estas moléculas juegan un papel importante en la fisiopatología de distintas enfermedades, por lo cual las lágrimas han sido de gran interés para la comunidad científica en la búsqueda de biomarcadores y en el desarrollo de estrategias terapéuticas para enfermedades sistémicas y oculares. La poca invasividad y el bajo riesgo al obtener la lágrima la convierten en una interesante muestra en comparación con algunos fluidos corporales que pueden ser mucho más costosos y molestos para su obtención. Lo anterior ha sido demostrado en diversos estudios que sugieren estrategias para obtener la muestra e indican un posterior análisis mediante avanzadas técnicas de biología molecular y celular, entre ellas los análisis ómicos, que han logrado una mejor caracterización lagrimal.Los análisis ómicos han contribuido en la identificación diferencial de distintas moléculas que pueden desempeñar un papel importante en el diagnóstico, seguimiento y/o tratamiento de enfermedades oculares y sistémicas. Por tanto, el propósito del presente artículo fue describir las diferentes características del fluido lagrimal, así como los posibles candidatos de biomarcadores de patologías oculares y sistémicas reportadosspa
dc.description.abstractenglishThe lacrimal fluid is characterized by a mixture of molecules from proteins, lipids, metabolites among others, which play an important role in the pathophysiology of different diseases, for which it has been of great interest in the scientific community for the search of biomarkers and development of therapeutic strategies in systemic and eye diseases. The lower invasiveness and risk when obtaining the tear, makes it an interesting sample compared to some bodily fluids that can be much more expensive and annoying to obtain. The above has been demonstrated through various studies in which they suggest different strategies to obtain the sample and its subsequent analysis using techniques of molecular and cellular biology among them advanced molecular technology such as those such as omic analyses, which have achieved a better lacrimal characterization. These analyses have contributed to the differential identification of different molecules that may play an important role in the diagno-sis, monitoring and/or treatment of eye and systemic diseases. The purpose of this article is to describe the different characteristics of the tear fluid as well as the possible candidates for biomarkers of mainly reported eye and systemic pathologieseng
dc.format.mimetypeapplication/pdf
dc.identifier.doiDOI: https://doi.org/10.18270/rsb.v10i1.2787
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2322-9462
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5817
dc.language.isospa
dc.publisher.journalRevista Salud Bosquespa
dc.relation.ispartofseriesRev. salud. bosque /ISSN 2322-946 / Volumen 10 /ene. - jun . de 2020 / Número 1/ Págs. 53-6spa
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dc.relation.urihttps://revistasaludbosque.unbosque.edu.co/index.php/RSB/article/view/2787
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectLágrimaspa
dc.subjectBiomarcadorspa
dc.subjectProteínaspa
dc.subjectEpigenéticaspa
dc.subjectSuperficie ocularspa
dc.subject.keywordsTearspa
dc.subject.keywordsBiomarkerspa
dc.subject.keywordsProteinspa
dc.subject.keywordsEpigeneticspa
dc.subject.keywordsOcular Surfacespa
dc.titleColombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.spa
dc.title.translatedTear film biomarkers and its clinical applicationspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revistaspa

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