Accuracy of cotinine serum test to detect the smoking habit and its association with periodontal disease in a multicenter study

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dc.contributor.authorDuque, Andrés
dc.contributor.authorMartínez, Paula-Juliana
dc.contributor.authorGiraldo, Astrid
dc.contributor.authorGualtero, Diego Fernando
dc.contributor.authorArdila, Carlos-Martín
dc.contributor.authorContreras, Adolfo
dc.contributor.authorDuarte, Silvia
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidGualtero, Diego Fernando [0000-0002-6407-5605]
dc.date.accessioned2020-11-04T17:45:40Z
dc.date.available2020-11-04T17:45:40Z
dc.date.issued2017
dc.description.abstractenglishThe validity of the surveys on self-reported smoking status is often questioned because smokers underestimate cigarette use and deny the habit. It has been suggested that self-report should be accompanied by cotinine test. This report evaluates the usefulness of serum cotinine test to assess the association between smoking and periodontal status in a study with a large sample population to be used in studies with other serum markers in epidemiologic and periodontal medicine researches. 578 patients who were part of a multicenter study on blood biomarkers were evaluated about smoking and its relation to periodontal disease. Severity of periodontal disease was determinate using clinical attachment loss (CAL). Smoking was assessed by a questionnaire and a blood sample drawn for serum cotinine determination. The optimal cut-off point for serum cotinine was 10 ng/ml. Serum cotinine showed greater association with severity of CAL than self-report for mild-moderate CAL [OR 2.03 (CI95% 1.16-3.53) vs. OR 1.08 (CI95% 0.62-1.87) ] advanced periodontitis [OR 2.36 (CI95% 1.30- 4.31) vs. OR 2.06 (CI95% 0.97-4.38) ] and extension of CAL > 3 mm [ OR 1.78 (CI95% 1.16-1.71) vs. 1.37 (CI95% 0.89-2.11)]. When the two tests were evaluated together were not shown to be better than serum cotinine test. Self-reported smoking and serum cotinine test ≥ 10ng/ml are accurate, complementary and more reliable methods to assess the patient's smoking status and could be used in studies evaluating serum samples in large population and multicenter studies. The serum cotinine level is more reliable to make associations with the patient's periodontal status than self-report questionnaire and could be used in multicenter and periodontal medicine studies.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4317/medoral.21292
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1698-6946
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4625
dc.language.isoeng
dc.publisherMedicina Oral S. L.spa
dc.publisher.journalMedicina Oral, Patología Oral y Cirugía Bucalspa
dc.relation.ispartofseriesMedicina Oral, Patología Oral y Cirugía Bucal, 1698-6946, Vol. 22, No. 4, 2017, p. 425-431spa
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/28578367/
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.subject.keywordsBiological markersspa
dc.subject.keywordsSerumspa
dc.subject.keywordsCotininespa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsSmokingspa
dc.titleAccuracy of cotinine serum test to detect the smoking habit and its association with periodontal disease in a multicenter studyspa
dc.title.translatedAccuracy of cotinine serum test to detect the smoking habit and its association with periodontal disease in a multicenter studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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