Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide

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dc.contributor.advisorRomero Sánchez, María Consuelo
dc.contributor.advisorBautista Molano, Wilson Armando
dc.contributor.advisorLafaurie, Gloria Ines
dc.contributor.authorUnriza-Puin, Sonia R.
dc.date.accessioned2021-09-10T17:16:02Z
dc.date.available2021-09-10T17:16:02Z
dc.date.issued2016
dc.description.abstractAntecedentes: Los estudios de asociación de AR han dirigido su atención hacia las fases preclínicas o asintomáticas en individuos sanos con alto riesgo de desarrollar AR. Datos previos demuestran que los familiares en primer grado de pacientes con AR (FPG) presentan una condición periodontal inflamatoria significativa que podría modular la severidad de la presentación clínica de la AR. Comparar la condición clínica periodontal y los niveles de anticuerpos contra Porphyromona gingivalis (Pg) en individuos FPG de pacientes con AR y controles sanos. Se evaluaron 100 individuos FPG y 200 individuos sanos como grupo control, pareados por edad y género. Se realizó valoración reumatológica y periodontal. Se midieron anticuerpos contra Pg y anticuerpos antipéptido citrulinado (anti-CCP). Se compararon los grupos aplicando pruebas de McNemar y de Signos de Wilcoxon y se realizaron modelos de regresión logística condicional para establecer asociaciones de EP y otros factores asociados al riesgo a AR en FPG. El 79% del grupo FPG presentó EP comparado con un 56% del grupo control (p=0.001). Siendo el 15% EP severa en el grupo FPG vs 9% en el grupo control (p=0.009). Se observó asociación significativa de la presencia de EP en el grupo FPG (OR: 3, 95% CI 1.89–7.29). Un 17% de obesidad en el grupo FPG comparado con un 7.5% del grupo control (p=0.008); observándose una asociación significativa para la presencia de obesidad en FPG (OR: 2.9, 95% CI .03-8.28). La presencia de anticuerpos anti-CCP fue del 7% en FPG vs 2.5% del grupo control, mostrando una asociación significativa en el análisis bivariado (p=0.038). Aunque en el análisis multivariado no logró soportar la asociación (OR: 2.4, 95% CI 0.7-8.32), los resultados parecen indicar una tendencia a su incremento en individuos FPG. Los anticuerpos anti-Pg (IgG1-IgG2) no mostraron diferencias significativas, entre los grupos. La presencia de EP, la obesidad y la presencia de anticuerpos anti-CCP pueden ser variables que condicionan el riesgo en individuos FPG.spa
dc.description.abstractenglishAssociation studies in rheumatoid arthritis (RA) have been focused in the pre-clinical phases of the disease in asymptomatic individuals with higher risk to develop RA. Previous data has shown that first degree relatives (FDR) of patients with RA have a periodontal condition that may modulate the severity and the clinical presentation of RA. To compare the periodontal condition and levels of antibody against Porphyromona gingivalis (Pg) between FDR individuals and healthy controls. In total, 100 FDR individuals and 200 healthy controls paired by age and gender were included. Rheumatologic and periodontal assessment was performed as well as antibodies anti-Pg and antibodies anti-citrullinated peptides (anti-CCP). The group-comparisons were analyzed using McNemar and Wilcoxon tests. A conditional logistic regression analyses was performed to establish associations between periodontitis and additional risk factors for RA in FDR. In the FDR-group 79% had periodontitis in comparison with control group 56% (p=0.001). Fifty percent of severe periodontitis was observed in FDR vs 9% in control group (p=0.009). A significant association was found in the FDR individuals regarding the presence of periodontitis (OR: 3, 95% CI 1.89–7.29). In the group of FDR 17% had obesity, compared to 7.5% of obesity in the control group. Additionally, there was association related to the presence of obesity in the FDR group (OR: 2.9, 95% CI .03-8.28). Anti –CCP antibodies was found in 7% in FDR group vs 2.5 % in control group; in the bivariate analysis a significant association (p=0.038) was found. Although the multivariate analysis did not support the association (OR: 2.4, 95% CI 0.7- 8.32), this results shows a trend towards the increase of anti-CCP antibodies in FDR group (OR: 2.4, 95% CI 0.7- 8.32). Regarding the antibodies anti Pg (IgG1-IgG2), no differences was found between the groups. The presence of periodontitis, obesity and the presence of anti-CCP antibodies may be factors influencing the risk in FDR of patients with RA.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias Odontológicasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/6049
dc.language.isospa
dc.publisher.facultyFacultad de Odontologíaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programMaestría en Ciencias Odontológicasspa
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dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons2016-05
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectPeriodontitisspa
dc.subjectArtritis reumatoidespa
dc.subjectObesidadspa
dc.subjectPéptido citrulinado cíclicospa
dc.subjectFamiliares primer gradospa
dc.subject.decsPeriodontitisspa
dc.subject.decsArtritis reumatoidespa
dc.subject.decsObesidadspa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsRheumatoid arthritisspa
dc.subject.keywordsObesityspa
dc.subject.keywordsAntibodies anticitrullinated peptidesspa
dc.subject.keywordsRelativesspa
dc.subject.nlmWU 100
dc.titleComparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoidespa
dc.title.translatedPeriodontal status and levels of antibody anti-P. gingivalis in individuals with higher risk to develop rheumatoid arthritisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Maestríaspa

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