Chronic joint pain 3 years after Chikungunya virus infection largely characterized by relapsing-remitting symptoms

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dc.contributor.authorTritsch, Sarah R.
dc.contributor.authorEncinales, Liliana
dc.contributor.authorPacheco, Nelly
dc.contributor.authorCadena, Andres
dc.contributor.authorCure, Carlos
dc.contributor.authorMcMahon, Elizabeth
dc.contributor.authorWatson, Hugh
dc.contributor.authorPorras-Ramírez, Alexandra
dc.contributor.authorRico Mendoza, Alejandro
dc.contributor.authorLi, Guangzhao
dc.contributor.authorKhurana, Kunal
dc.contributor.authorJaller-Raad, Juan José
dc.contributor.authorCastillo, Stella Mejia
dc.contributor.authorBarrios Taborda, Onaldo
dc.contributor.authorJaller-Char, Juan Jose
dc.contributor.authorAvendaño Echavez, Lil G
dc.contributor.authorJiménez, Dennys
dc.contributor.authorGonzález Coba, Andrés
dc.contributor.authorAlarcon Gomez, Magda
dc.contributor.authorAriza Orozco, Dores
dc.contributor.authorBravo, Eyda
dc.contributor.authorMartinez, Victor
dc.contributor.authorGuerra, Brenda
dc.contributor.authorSimon, Gary L.
dc.contributor.authorFirestein, Gary S.
dc.contributor.authorChang, Aileen
dc.contributor.orcidPorras-Ramírez, Alexandra [0000-0002-0800-1388]
dc.date.accessioned2020-08-19T19:53:30Z
dc.date.available2020-08-19T19:53:30Z
dc.date.issued2020
dc.description.abstractenglishOBJECTIVE: To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus (CHIKV) in a Latin American cohort. METHODS: A cross-sectional followup of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having CHIKV during the 2014-2015 epidemic, and baseline and followup symptoms at 40 months were evaluated in serologically confirmed cases. RESULTS: Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for CHIKV infection had persistent joint pain 3 years after infection. Participants who followed up in person were predominantly adult (mean ± SD age 51 ± 14 yrs) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. CONCLUSION: To our knowledge, this is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoideng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3899/jrheum.190162
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1499-2752
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3815
dc.language.isoeng
dc.publisherJournal of Rheumatology Publishing Co., Ltd.spa
dc.publisher.journalJournal of rheumatologyspa
dc.relation.ispartofseriesJournal of rheumatology, 1499-2752, Vol. 47, Nro. 8, 2020, p. 1267-1274spa
dc.relation.urihttps://www.jrheum.org/content/47/8/1267.long
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-08-01
dc.rights.localAcceso abiertospa
dc.subject.keywordsArthritisspa
dc.subject.keywordsClinical trialsspa
dc.subject.keywordsInfectionspa
dc.subject.keywordsInflammationspa
dc.titleChronic joint pain 3 years after Chikungunya virus infection largely characterized by relapsing-remitting symptomsspa
dc.title.translatedChronic joint pain 3 years after Chikungunya virus infection largely characterized by relapsing-remitting symptomsspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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