Meningococcemia as an initial manifestation of systemic lupus erythematosus: Report of a case and review of the literature

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dc.contributor.authorAponte, Jorge Enrique
dc.contributor.authorForero, Yency
dc.contributor.authorDiaz, Martha
dc.contributor.authorEstupiƱan, Maria Fernanda
dc.contributor.authorZapata, Martin
dc.contributor.authorSanchez, Alexander
dc.contributor.authorOspina, Maria Teresa
dc.contributor.authorZambrano, Paula
dc.contributor.authorHurtado, Diana
dc.date.accessioned2020-08-04T13:26:10Z
dc.date.available2020-08-04T13:26:10Z
dc.date.issued2017
dc.description.abstractenglishSystemic lupus erythematosus (SLE) is an inflammatory disease with a wide range of clinical manifestations and complications related to disease activity. One of them is the increase risk to infections secondary to immunological alterations due to pharmacological therapy (especially steroids). Few reports have documented the association of SLE and meningococcal infection with subsequent development of immunological activation (continuous inflammation) and intolerance of the immune system. The attempts to make an early and appropriate approach to these type of patients, generate benefits in survival rates and decrease sequelae among those who survive, especially in those in whose infection compromised central nervous system. We present the case of a patient that presented with neurological symptoms compatible with neuroeffector by Neisseria meningitis isolated in CSF cultures. Despite adequate antibiotic treatment the patient continued to deteriorate neurologically, and alternative diagnosis were evaluated after findings of vasculitis in brain CT scan. Immunological panel was performed with positivity of antibodies commonly present in SLE considering that infection by Neisseria meningitis was a trigger of immunological intolerance and development of SLE. We present the following case to understand the physiopathology and relationship between meningococcal infections, complement consumption, immunological intolerance and the development of autoimmune disease.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.21767/AMJ.2017.3234
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1836-1935
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3655
dc.language.isoeng
dc.publisherThe Australasian Medical Journalspa
dc.publisher.journalAustralasian Medical Journalspa
dc.relation.ispartofseriesAustralasian Medical Journal, 1836-1935, Vol. 10, Nro. 12, 2017, p. 1036-1041spa
dc.relation.urihttps://www.amj.net.au/index.php/AMJ/article/view/3234
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.subject.keywordsMeningococcal sepsisspa
dc.subject.keywordsSystemic lupus erythematosusspa
dc.subject.keywordsMortalityspa
dc.titleMeningococcemia as an initial manifestation of systemic lupus erythematosus: Report of a case and review of the literaturespa
dc.title.translatedMeningococcemia as an initial manifestation of systemic lupus erythematosus: Report of a case and review of the literaturespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtĆ­culo de revista

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