Vigilancia centinela de la meningitis bacteriana pediátrica en un hospital pediátrico de IV nivel en Colombia, 2016-2022

Bautista Chaves, Adriana Marcela

Vigilancia centinela de la meningitis bacteriana pediátrica en un hospital pediátrico de IV nivel en Colombia, 2016-2022

dc.contributor.advisor	Porras Ramírez, Alexandra
dc.contributor.author	Bautista Chaves, Adriana Marcela
dc.date.accessioned	2024-08-29T19:44:48Z
dc.date.available	2024-08-29T19:44:48Z
dc.date.issued	2024-05
dc.description.abstract	Objetivo: Describir la etiología, epidemiología y presentación clínica de los pacientes menores de 5 años con MB en el HOMI de 2016 a 2022. Materiales y métodos: Estudio descriptivo de niños menores de 5 años con sospecha de MB. Los casos probables fueron aquellos que tuvieron un resultado de LCR compatible con MB. Los casos confirmados tuvieron un cultivo de LCR o hemocultivo positivo para un patógeno o una prueba molecular positiva para una bacteria en el LCR. Se analizaron variables demográficas, la incidencia de MB por año y la asociación de factores de riesgo con mortalidad o secuelas en pacientes vivos. Resultados: Se estudiaron 449 casos sospechosos de MB; 24.5% (n = 110/449) fueron casos probables y 53.6% (n = 59/110) fueron casos confirmados. El 32.7% de los casos probables y el 37.3% de los casos confirmados fueron menores de 2 años. Los signos y síntomas más frecuentes en los casos confirmados fueron fiebre (84,7%), alteración de la conciencia (40,7%), convulsiones (37,3%) y letargo (32,2%). La tasa de mortalidad fue de 3,3% (n = 2/59); la estancia hospitalaria promedio fue de 34,5 días. Se identificó Spn en 22% y 40% fueron serotipo 15C, Hi en 18,6% y 66,6% tuvieron serotipo b, y Nm en 10,1% y 75% fueron serogrupo C. Otros agentes se observaron en 49,1% de los pacientes. Conclusión: La vigilancia centinela permite medir el impacto de las intervenciones de salud pública y evaluar el impacto de las vacunas ya utilizadas.
dc.description.abstractenglish	Objective: To describe the etiology, epidemiology, and clinical presentations of patients under 5 years of age with BM at HOMI from 2016 to 2022. Materials and methods: Descriptive study of children under 5 years of age with suspected BM. Probable cases were those that had a CSF result consistent with BM. Confirmed cases had a positive CSF culture or blood culture for a pathogen or a positive molecular test for a bacterium in the CSF. Demographic variables, the incidence of BM per year and the association of risk factors with mortality or sequelae in living patients were analyzed. Results: 449 suspected cases of BM were studied; 24.5% (n = 110/449) were probable cases, and 53.6% (n = 59/110) were confirmed cases. 32.7% of the probable cases and 37.3% of confirmed cases were under 2 years of age. The most frequent signs and symptoms in the cases confirmed were fever (84.7%), altered consciousness (40.7%), seizures (37.3%) and lethargy (32.2%). The mortality rate was 3.3% (n = 2/59); the average hospital stays were 34.5 days. Spn was identified in 22% and 40% were serotype 15C, Hi in 18.6% and 66.6% had serotype b, and Nm in 10.1% and 75% of were serogroup C. Other agents were observed in 49.1% patients. Conclusion: Sentinel surveillance makes it possible to measure the impact of public health interventions and evaluate the impact of vaccines already used.
dc.description.degreelevel	Maestría	spa
dc.description.degreename	Magíster en Epidemiología	spa
dc.description.sponsorship	Hospital Pediatrico la Misericordia
dc.description.sponsorship	Organización Panamericana de la Salud
dc.description.sponsorship	Secretaria de Salud de Bogotá
dc.description.sponsorship	Instituto Nacional de Salud
dc.format.mimetype	application/pdf
dc.identifier.instname	instname:Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/12915
dc.language.iso	en
dc.publisher.faculty	Facultad de Medicina	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Maestría en Epidemiología	spa
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dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	https://purl.org/coar/access_right/c_abf2
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Meningitis
dc.subject	Streptococcus pneumoniae
dc.subject	Haemophilus influenzae, Neisseria meningitidis, centinela.
dc.subject	Neisseria meningitidis
dc.subject	Centinela
dc.subject.keywords	Meningitis
dc.subject.keywords	Streptococcus pneumoniae
dc.subject.keywords	Haemophilus influenzae
dc.subject.keywords	Neisseria meningitidis
dc.subject.keywords	Sentinel
dc.subject.nlm	WA 105
dc.title	Vigilancia centinela de la meningitis bacteriana pediátrica en un hospital pediátrico de IV nivel en Colombia, 2016-2022
dc.title.translated	Sentinel surveillance on pediatric bacterial meningitis in a IV level pediatric hospital in Colombia, 2016-2022
dc.type.coar	https://purl.org/coar/resource_type/c_bdcc
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/masterThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Maestría	spa