Hepatitis B infection control in Colombian Amazon after 15 years of hepatitis B vaccination. Effectiveness of birth dose and current prevalence

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dc.contributor.authorGarcia, Diego
dc.contributor.authorPorras-Ramírez, Alexandra
dc.contributor.authorRico Mendoza, Alejadro
dc.contributor.authorAlvis, Nelson
dc.contributor.authorNavas, Maria Cristina
dc.contributor.authorDe La Hoz, Fernando
dc.contributor.authorDe Neira, Marlen
dc.contributor.authorOsorio, Elkin
dc.contributor.authorValderrama, José Fernando
dc.contributor.orcidPorras-Ramírez, Alexandra [0000-0002-0800-1388]
dc.date.accessioned2020-07-30T16:57:22Z
dc.date.available2020-07-30T16:57:22Z
dc.date.issued2018
dc.description.abstractenglishBackground Hepatitis B virus (HBV) infection is highly endemic in the Colombian Amazon basin. In Colombia, the universal hepatitis B vaccination in that area has been active since 1993. The program targets children aged under five years. Newborns receive at least three doses, and in 2001, HBV vaccine birth dose was included. This study aimed to evaluate the advances on HBV control in the Colombian Amazon. Methods A population-based cross-sectional study was conducted in children less than 11 years old in rural areas of the Colombian Amazon, in order to assess the current levels of HBV prevalence and evaluate the effectiveness of HBV vaccination. Participants were selected from villages scattered along the Amazon, Putumayo and Loretoyaco Rivers. Blood samples were taken from children. All the samples were examined for surface antigen (HBsAg) and IgG antibodies against core antigen (AntiHBc) of HBV. Data on HBV vaccination status and other risk factors were also collected. Results Blood samples from 1275 children were included in the study. The positivity for IgG AntiHBC and HBsAg was 3.8% and 0.5%, respectively. It was observed that receiving a dose of HBV vaccine within 48 h after birth decreased the risk of HBV infection and carriage by 95%. Being born to an AntiHBc positive mother increased 8 times the risk of HBV infection (OR  =  7.8 CI 95% 3.3–10.2) and 7 times the risk of HBsAg carriage (OR  =  6.6 CI 95% 2.1–10.1). Conclusion The prevalence of HBV infection and HBsAg carriage continues to decrease among children living in the Colombian Amazon. The high protective effectiveness of an HBV birth does suggest that perinatal transmission is important in endemic areas of Latin America, an aspect that has not been fully studied in the region.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2017.11.004
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0264-410X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3621
dc.language.isoeng
dc.publisher.journalVaccinespa
dc.relation.ispartofseriesVaccine, 0264-410X, Vol. 36, Nro. 19, 2018, p. 2721-2726spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X17315463?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2018-05-03
dc.rights.localAcceso abiertospa
dc.subject.keywordsHepatitis Bspa
dc.subject.keywordsPrevalencespa
dc.subject.keywordsEffectiveness of HBV birth dosespa
dc.subject.keywordsColombiaspa
dc.titleHepatitis B infection control in Colombian Amazon after 15 years of hepatitis B vaccination. Effectiveness of birth dose and current prevalencespa
dc.title.translatedHepatitis B infection control in Colombian Amazon after 15 years of hepatitis B vaccination. Effectiveness of birth dose and current prevalencespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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