Comparación de la transferencia de anticuerpos contra covid 19 a neonatos de madres vacunadas vs madres que cursaron con infección por sars cov2 durante la gestación

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dc.contributor.advisorCastellanos, Jaime Eduardo
dc.contributor.advisorRomero Infante, Ximena Carolina
dc.contributor.advisorDe la Hoz Valle, José Antonio
dc.contributor.authorOjeda Reyes, Andrea Veronica
dc.contributor.orcidOjeda Reyes, Andrea Verónica [0000-0003-3004-965X]
dc.date.accessioned2024-08-02T14:54:19Z
dc.date.available2024-08-02T14:54:19Z
dc.date.issued2024-07
dc.description.abstractLas diferencias en la producción de anticuerpos para SARS CoV-2 posterior a la infección y la inmunización, las variaciones en la capacidad de neutralización y la transferencia de anticuerpos durante la gestación constituyen un tema de interés en la comprensión de la protección del neonato ante una exposición al virus. Este estudio comparó la transferencia de anticuerpos IgG y anticuerpos neutralizantes entre los neonatos de madres vacunadas contra SARS-CoV-2 durante o antes de la gestación y las que cursaron infección en el embarazo, así como la presencia de infecciones respiratorias en sus neonatos. Métodos: Se realizó un estudio de cohorte multicéntrico en cuatro centros hospitalarios en la ciudad de Bogotá (Colombia) durante marzo de 2023 hasta octubre de 2023. Se recolectaron muestras de sangre materna y de cordón umbilical de 86 díadas, 40 vacunadas durante la gestación (46.5%), 35 con vacunación antes del embarazo (40.6%), y 11 de infectadas por SARS-CoV-2 en el embarazo (12.8%), para la evaluación de anticuerpos IgG y anticuerpos neutralizantes. Se aplicó la prueba exacta de Fisher para variables categóricas y ANOVA para el análisis de variables continuas. Se correlacionaron los anticuerpos neutralizantes maternos y de cordón umbilical con el coeficiente de correlación de Pearson. La asociación entre anticuerpos neutralizantes en sangre materna y cordón umbilical se evaluó mediante regresión logística.
dc.description.abstractenglishDifferences in antibody production against SARS-CoV-2 exist as a result of infection and immunization, as well as variations in neutralization capacity and transfer of antibodies during pregnancy. Further data on these mechanisms can provide understanding of newborn protection against exposure to the virus and the evaluation of the vaccination scheme during pregnancy. This study compared the IgG and neutralizing antibodies transfer between neonates born from mothers vaccinated against SARS-CoV-2 during or before gestation and those who were infected during pregnancy, as well as the presence of respiratory infections in their neonates. Methods: A multicenter cohort study was conducted in four hospitals in Bogotá, Colombia, between March and October 2023. This study evaluated IgG and neutralizing antibodies using blood samples from pregnant women and umbilical cord blood from 86 mother-child pairs. The cohort included 40 mothers vaccinated during pregnancy (46.5%), 35 vaccinated before pregnancy (40.6%), and 11 infected with SARS-CoV-2 during pregnancy (12.8%). Fisher's exact test was applied for categorical variables and ANOVA to analyze continuous variables. Maternal-neutralizing antibodies and umbilical cord-neutralizing antibodies were correlated using the Pearson correlation coefficient. The association between neutralizing antibodies in the maternal and umbilical cord blood was evaluated using logistic regression.
dc.description.degreelevelEspecializaciónspa
dc.description.degreenameEspecialista en Medicina Materno-Fetalspa
dc.description.sponsorshipHospital Universitario Clínica San Rafael
dc.description.sponsorshipCentro Policlínico del Olaya
dc.description.sponsorshipLos Cobos Medical Center
dc.description.sponsorshipSubred Integrada de Servicios de Salud Suroccidente E.S.E
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/12800
dc.language.isoes
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programEspecialización en Medicina Materno-Fetalspa
dc.relation.references[1] Instituto Nacional de Salud. Boletín No. 38. COVID-19 en gestantes y neonatos en Colombia 2024. https://www.ins.gov.co/Noticias/Paginas/coronavirus-gestantes-y-neonatos.aspx (accessed December 11, 2023).
dc.relation.references[2] Mathad JS, Gupta A. Pulmonary Infections in Pregnancy. Semin Respir Crit Care Med 2017;38:174–84. https://doi.org/10.1055/S-0037-1602375.
dc.relation.references[3] Rasmussen SA, Jamieson DJ, Uyeki TM. Effects of influenza on pregnant women and infants. Am J Obstet Gynecol 2012;207:53–8. https://doi.org/10.1016/J.AJOG.2012.06.068.
dc.relation.references[4] Wang H, Li N, Sun C, Guo X, Su W, Song Q, et al. The association between pregnancy and COVID-19: A systematic review and meta-analysis. Am J Emerg Med 2022;56:188–95. https://doi.org/10.1016/J.AJEM.2022.03.060.
dc.relation.references[5] Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020;370:m3320. https://doi.org/10.1136/BMJ.M3320.
dc.relation.references[6] Rasmussen SA, Jamieson DJ. Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021. JAMA 2021;325:1099–100. https://doi.org/10.1001/JAMA.2021.1683.
dc.relation.references[7] Luxi N, Giovanazzi A, Capuano A, Crisafulli S, Cutroneo PM, Fantini MP, et al. COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety. Drug Saf 2021;44:1247–69. https://doi.org/10.1007/S40264-021-01131-6.
dc.relation.references[8] Jering KS, Claggett BL, Cunningham JW, Rosenthal N, Vardeny O, Greene MF, et al. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. JAMA Intern Med 2021;181:714–7. https://doi.org/10.1001/JAMAINTERNMED.2020.9241.
dc.relation.references[9] Birol Ilter P, Prasad S, Berkkan M, Mutlu MA, Tekin AB, Celik E, et al. Clinical severity of SARS‐CoV‐2 infection among vaccinated and unvaccinated pregnancies during the Omicron wave. Ultrasound in Obstetrics & Gynecology 2022;59:560–2. https://doi.org/10.1002/UOG.24893.
dc.relation.references[10] Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine 2021;384:403–16. https://doi.org/10.1056/NEJMOA2035389/SUPPL_FILE/NEJMOA2035389_DATA-SHARING.PDF.
dc.relation.references[11] Verdecia M, Kokai-Kun JF, Kibbey M, Acharya S, Venema J, Atouf F. COVID-19 vaccine platforms: Delivering on a promise? Hum Vaccin Immunother 2021;17:2873–93. https://doi.org/10.1080/21645515.2021.1911204.
dc.relation.references[12] Graña C, Ghosn L, Evrenoglou T, Jarde A, Minozzi S, Bergman H, et al. Efficacy and safety of COVID‐19 vaccines. Cochrane Database Syst Rev 2022;2022:CD015477. https://doi.org/10.1002/14651858.CD015477.
dc.relation.references[13] Konje JC, Al Beloushi M, Ahmed B. Immunisation against COVID-19 in Pregnancy and of Women Planning Pregnancy. Viruses 2023;15:621. https://doi.org/10.3390/V15030621.
dc.relation.references[14] Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T, Panagiotakopoulos L, et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. New England Journal of Medicine 2021;384:2273–82. https://doi.org/10.1056/NEJMOA2104983/SUPPL_FILE/NEJMOA2104983_DATA-SHARING.PDF.
dc.relation.references[15] Blakeway H, Prasad S, Kalafat E, Heath PT, Ladhani SN, Le Doare K, et al. COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol 2022;226:236.e1-236.e14. https://doi.org/10.1016/J.AJOG.2021.08.007.
dc.relation.references[16] Goldshtein I, Nevo D, Steinberg DM, Rotem RS, Gorfine M, Chodick G, et al. Association Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women. JAMA 2021;326:728–35. https://doi.org/10.1001/JAMA.2021.11035.
dc.relation.references[17] The American College of Obstetricians and Gynecologists (ACOG). COVID-19 Vaccination Considerations for Obstetric–Gynecologic Care 2023. https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/covid-19-vaccination-considerations-for-obstetric-gynecologic-care (accessed February 25, 2024).
dc.relation.references[18] The American College of Obstetricians and Gynecologists (ACOG). ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals 2021. https://www.acog.org/news/news-releases/2021/07/acog-smfm-recommend-covid-19-vaccination-for-pregnant-individuals (accessed February 25, 2024).
dc.relation.references[19] World Health Organization. Questions and answers: COVID-19 vaccines and pregnancy, 15 February 2022 2022. https://iris.who.int/handle/10665/351855.
dc.relation.references[20] Collier ARY, McMahan K, Yu J, Tostanoski LH, Aguayo R, Ansel J, et al. Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women. JAMA 2021;325:2370–80. https://doi.org/10.1001/JAMA.2021.7563.
dc.relation.references[21] Beharier O, Mayo RP, Raz T, Sacks KN, Schreiber L, Suissa-Cohen Y, et al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest 2021;131:e150319. https://doi.org/10.1172/JCI150319.
dc.relation.references[22] Documento técnico vacunación gestantes Covid junio - Fecolsog n.d. https://fecolsog.org/uncategorized/documento-tecnico-vacunacion-gestantes-covid-junio/ (accessed September 26, 2021).
dc.relation.references[23] Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, et al. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol 2021;225:303.e1-303.e17. https://doi.org/10.1016/J.AJOG.2021.03.023/ATTACHMENT/90F348A2-C98D-43DC-9F64-B558B5381DDE/MMC3.MP4.
dc.relation.references[24] Cosma S, Carosso AR, Corcione S, Cusato J, Borella F, Antonucci M, et al. Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery. J Reprod Immunol 2021;144:103285. https://doi.org/10.1016/J.JRI.2021.103285.
dc.relation.references[25] Cassaniti I, Percivalle E, Zelini P, Nanhorngue KN, Parolo A, Bernardi V, et al. Both SARS-CoV-2 infection and vaccination in pregnancy elicited neutralizing antibodies in pregnant women and newborns. Clinical Microbiology and Infection 2021;27:1708-170+. https://doi.org/10.1016/J.CMI.2021.08.004.
dc.relation.references[26] Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, et al. Compromised SARS-CoV-2-specific placental antibody transfer. Cell 2021;184:628. https://doi.org/10.1016/J.CELL.2020.12.027.
dc.relation.references[27] Paul G, Chad R. Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report. BMC Pediatrics 2021 21:1 2021;21:1–2. https://doi.org/10.1186/S12887-021-02618-Y.
dc.relation.references[28] Heininger U, Riffelmann M, Leineweber B, Wirsing Von Koenig CH. Maternally derived antibodies against bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns. Pediatric Infectious Disease Journal 2009;28:443–5. https://doi.org/10.1097/INF.0B013E318193EAD7.
dc.relation.references[29] Atyeo C, Shook LL, Nziza N, Deriso EA, Muir C, Baez AM, et al. COVID-19 booster dose induces robust antibody response in pregnant, lactating, and nonpregnant women. Am J Obstet Gynecol 2023;228:68.e1. https://doi.org/10.1016/J.AJOG.2022.07.014.
dc.relation.references[30] Munoz FM, Posavad CM, Richardson BA, Badell ML, Bunge KE, Mulligan MJ, et al. COVID-19 booster vaccination during pregnancy enhances maternal binding and neutralizing antibody responses and transplacental antibody transfer to the newborn. Vaccine 2023;41:5296–303. https://doi.org/10.1016/J.VACCINE.2023.06.032.
dc.relation.references[31] Jacobs MB, Valentine HD, Adkins S, Magallanes C, Morgan SC, Pereira LM, et al. Humoral immune response to SARS-CoV-2 in pregnant and nonpregnant women following infection. AJOG Global Reports 2023;3:100192. https://doi.org/10.1016/J.XAGR.2023.100192.
dc.relation.references[32] Palmeira P, Quinello C, Silveira-Lessa AL, Zago CA, Carneiro-Sampaio M. IgG Placental Transfer in Healthy and Pathological Pregnancies. Clin Dev Immunol 2012;2012:985646. https://doi.org/10.1155/2012/985646.
dc.relation.references[33] Malek A, Sager R, Kuhn P, Nicolaides KH, Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol 1996;36:248–55. https://doi.org/10.1111/J.1600-0897.1996.TB00172.X.
dc.relation.references[34] Clements T, Rice TF, Vamvakas G, Barnett S, Barnes M, Donaldson B, et al. Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal Factors. Front Immunol 2020;11:1920. https://doi.org/10.3389/FIMMU.2020.01920/FULL.
dc.relation.references[35] Van Den Berg JP, Westerbeek EAM, Berbers GAM, Van Gageldonk PGM, Van Der Klis FRM, Van Elburg RM. Transplacental transport of IgG antibodies specific for pertussis, diphtheria, tetanus, haemophilus influenzae type b, and neisseria meningitidis serogroup C is lower in preterm compared with term infants. Pediatric Infectious Disease Journal 2010;29:801–5. https://doi.org/10.1097/INF.0B013E3181DC4F77.
dc.relation.references[36] Liu S, Wang P, Shi X, Weng T, Zhong J, Zhang X, et al. Maternal antibody transfer rate of vaccination against SARS-CoV-2 before or during early pregnancy and its protective effectiveness on offspring. J Med Virol 2023;95:e29125. https://doi.org/10.1002/JMV.29125.
dc.relation.references[37] Chi WY, Li Y Der, Huang HC, Chan TEH, Chow SY, Su JH, et al. COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection. J Biomed Sci 2022;29:82. https://doi.org/10.1186/S12929-022-00853-8.
dc.relation.references[38] Khoury DS, Cromer D, Reynaldi A, Schlub TE, Wheatley AK, Juno JA, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med 2021;27:1205–11. https://doi.org/10.1038/S41591-021-01377-8.
dc.relation.references[39] Feng S, Phillips DJ, White T, Sayal H, Aley PK, Bibi S, et al. Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection. Nat Med 2021;27:2032–40. https://doi.org/10.1038/S41591-021-01540-1.
dc.relation.references[40] Castro Dopico X, Ols S, Loré K, Karlsson Hedestam GB. Immunity to SARS-CoV-2 induced by infection or vaccination. J Intern Med 2022;291:32–50. https://doi.org/10.1111/JOIM.13372.
dc.relation.references[41] Laguila Altoé A, Marques Mambriz AP, Cardozo DM, Valentini Zacarias JM, Laguila Visentainer JE, Bahls-Pinto LD. Vaccine Protection Through Placenta and Breastfeeding: The Unmet Topic in COVID-19 Pandemic. Front Immunol 2022;13:910138. https://doi.org/10.3389/FIMMU.2022.910138.
dc.relation.references[42] Sharif N, Alzahrani KJ, Ahmed SN, Dey SK. Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis. Front Immunol 2021;12:714170. https://doi.org/10.3389/FIMMU.2021.714170.
dc.relation.references[43] Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011;1221:80–7. https://doi.org/10.1111/J.1749-6632.2010.05938.X.
dc.relation.references[44] Mor Gil, Abrahams Vikki M. Immunology of Pregnancy. Creasy and Resnik’s Maternal-Fetal Medicine, vol. 1, 2023, p. 127–42.
dc.relation.references[45] Tregoning JS, Weiner J, Cizmeci D, Hake D, Maertzdorf J, Kaufmann SHE, et al. Pregnancy has a minimal impact on the acute transcriptional signature to vaccination. NPJ Vaccines 2020;5:29. https://doi.org/10.1038/S41541-020-0177-6.
dc.relation.references[46] Lima J, Martins C, Leandro MJ, Nunes G, Sousa MJ, Branco JC, et al. Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study. BMC Pregnancy Childbirth 2016;16:139. https://doi.org/10.1186/S12884-016-0927-7.
dc.relation.references[47] Saeed Z, Greer O, Shah NM. Is the Host Viral Response and the Immunogenicity of Vaccines Altered in Pregnancy? Antibodies 2020;9:1–17. https://doi.org/10.3390/ANTIB9030038.
dc.relation.references[48] Shook LL, Fallah PN, Silberman JN, Edlow AG. COVID-19 Vaccination in Pregnancy and Lactation: Current Research and Gaps in Understanding. Front Cell Infect Microbiol 2021;11:735394. https://doi.org/10.3389/FCIMB.2021.735394/BIBTEX.
dc.relation.references[49] Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, et al. Neutralizing antibody activity against SARS-CoV-2 variants in gestational age–matched mother-infant dyads after infection or vaccination. JCI Insight 2022;7:e157354. https://doi.org/10.1172/JCI.INSIGHT.157354.
dc.relation.references[50] da Silva Filho AO, Gonçalves DN, de Lima LKR, da Silva Alves DAN, de Andrade Falcão FJ, Falcão REA. Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy. Vaccines (Basel) 2023;11:620. https://doi.org/10.3390/VACCINES11030620.
dc.relation.references[51] Murphy EA, Guzman-Cardozo C, Sukhu AC, Parks DJ, Prabhu M, Mohammed I, et al. SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates. Nat Commun 2023;14:4598. https://doi.org/10.1038/S41467-023-39989-Y.
dc.relation.references[52] Martínez-Quezada R, Miguel-Rodríguez CE, Ramírez-Lozada T, Valencia-Ledezma OE, Acosta-Altamirano G. Placental Transfer Efficiency of Neutralizing Antibodies on SARS-CoV-2 Vaccination before and after Pregnancy in Mexican Women. Int J Mol Sci 2024;25:1516. https://doi.org/10.3390/IJMS25031516.
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacionalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectVacunas
dc.subjectEmbarazo
dc.subjectAnticuerpos neutralizantes
dc.subjectRecien nacidos
dc.subject.keywordsSARS-CoV-2
dc.subject.keywordsCOVID-19 vaccines
dc.subject.keywordsPregnancy
dc.subject.keywordsNewborn
dc.subject.keywordsNeutralizing Antibodies
dc.subject.nlmWQ 200
dc.titleComparación de la transferencia de anticuerpos contra covid 19 a neonatos de madres vacunadas vs madres que cursaron con infección por sars cov2 durante la gestación
dc.title.translatedComparison of SARS-CoV-2 total and neutralizing Antibody Transfer to Neonates from Vaccinated Mothers vs Mothers Infected during Pregnancy: An observational study
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Especializaciónspa

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