Range expansion and the origin of USA300 North American Epidemic Methicillin-Resistant Staphylococcus aureus

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dc.contributor.authorChallagundla, Lavanya
dc.contributor.authorLuo, Xiao
dc.contributor.authorTickler, Isabella A.
dc.contributor.authorDidelot, Xavier
dc.contributor.authorColeman, David C.
dc.contributor.authorShore, Anna C.
dc.contributor.authorCoombs, Geoffrey W.
dc.contributor.authorSordelli, Daniel O.
dc.contributor.authorBrown, Eric L.
dc.contributor.authorSkov, Robert
dc.contributor.authorLarsen, Anders Rhod
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorRobledo, Iraida E.
dc.contributor.authorVazquez, Guillermo J.
dc.contributor.authorRivera, Raul
dc.contributor.authorFey, Paul D.
dc.contributor.authorStevenson, Kurt
dc.contributor.authorWang, Shu-Hua
dc.contributor.authorKreiswirth, Barry N.
dc.contributor.authorMediavilla, Jose R.
dc.contributor.authorArias, César A.
dc.contributor.authorPlanet, Paul J.
dc.contributor.authorNolan, Rathel L.
dc.contributor.authorTenover, Fred C.
dc.contributor.authorGoering, Richard V.
dc.contributor.authorRobinson, D. Ashley
dc.date.accessioned2019-08-27T13:50:05Z
dc.date.available2019-08-27T13:50:05Z
dc.date.issued2018
dc.description.abstractenglishThe USA300 North American epidemic (USA300-NAE) clone of methicillinresistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from the serial founder effects of a geographic range expansion to infer the origin of USA300-NAE and identify polymorphisms associated with its spread. Genome sequences from 357 isolates from 22 U.S. states and territories and seven other countries are compared. We observe two significant signatures of range expansion, including decreases in genetic diversity and increases in derived allele frequency with geographic distance from the Pennsylvania region. These signatures account for approximately half of the core nucleotide variation of this clone, occur genome wide, and are robust to heterogeneity in temporal sampling of isolates, human population density, and recombination detection methods. The potential for positive selection of a gyrA fluoroquinolone resistance allele and several intergenic regions, along with a 2.4 times higher recombination rate in a resistant subclade, is noted. These results are the first to show a pattern of genetic variation that is consistent with a range expansion of an epidemic bacterial clone, and they highlight a rarely considered but potentially common mechanism by which genetic drift may profoundly influence bacterial genetic variation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/mBio.02016-17
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2150-7511
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1657
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalmBiospa
dc.relation.ispartofseriesmBio, 2150-7511, Vol. 9, Nro. 1, 2018 p. 1-15spa
dc.relation.urihttps://mbio.asm.org/content/9/1/e02016-17
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf88
dc.rights.creativecommons2018
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsGenéticaspa
dc.subject.decsVariación genéticaspa
dc.subject.decsStaphylococcus aureus resistente a meticilinaspa
dc.subject.decsEpidemiologíaspa
dc.subject.keywordsEpidemicsspa
dc.subject.keywordsFluoroquinolonesspa
dc.subject.keywordsFounder effectsspa
dc.titleRange expansion and the origin of USA300 North American Epidemic Methicillin-Resistant Staphylococcus aureusspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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