Leukocyte-and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: A randomized clinical trial

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dc.contributor.authorPalma, Luiz Felipe
dc.contributor.authorMarcucci, Marcelo
dc.contributor.authorRemondes, Cíntia Maria
dc.contributor.authorChambrone, Leandro
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-11-20T19:16:24Z
dc.date.available2020-11-20T19:16:24Z
dc.date.issued2020
dc.description.abstractenglishBACKGROUND:One of the most important complications of radiotherapy (RT) for head and neck cancer (HNC) is osteoradionecrosis (ORN) of the jaws, arising mainly from tooth extractions. Thus, the present study aimed to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in preventing ORN following tooth extraction in post-irradiated HNC patients, as well as other postoperative complications. MATERIAL AND METHODS:23 patients previously submitted to conventionally fractionated 3D-conformational RT for HNC underwent atraumatic tooth extractions with perioperative antibiotic therapy. Besides, they were randomly assigned to receive L-PRF clots to fill and cover the extraction sockets (n=11, Test Group) or not (n=12, Control Group). A visual analog scale was used to quantify postoperative pain on the 3rd and 7th days. For ORN diagnosis, patients were clinically assessed for up to 180 days. Other postoperative complications (edema, alveolitis, suture dehiscence, continuous bleeding, and oroantral communication) were also evaluated within this period. RESULTS:No case of ORN or another surgical complication was observed and there were no differences in the postoperative pain scores between the groups on the 3rd and 7th days. CONCLUSIONS:L-PRF did not seem to provide any additional benefits than those achieved by the combination of the surgical and drug protocols used for tooth extractions in the post-irradiated HNC patients.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4317/medoral.23804
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1698-6946
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5099
dc.language.isoeng
dc.publisherMedicina Oral S.L.spa
dc.publisher.journalMedicina oral, patología oral y cirugía bucal,spa
dc.relation.ispartofseriesMedicina oral, patología oral y cirugía bucal, 1698-6946, Vol. 25, Nro. 6, 2020, p. e799-e804spa
dc.relation.urihttps://doi.org/10.4317/medoral.23804
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-10-31
dc.rights.localAcceso abiertospa
dc.subject.keywordsHead and neck cancerspa
dc.subject.keywordsOsteoradionecrosisspa
dc.subject.keywordsRadiotherapyspa
dc.subject.keywordsTooth extractionspa
dc.titleLeukocyte-and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: A randomized clinical trialspa
dc.title.translatedLeukocyte-and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: A randomized clinical trialspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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