Update on the epidemiology of carbapenemases in Latin America and the Caribbean
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2020
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Expert review of anti-infective therapy, 1744-8336, 2020
Publicado por
Taylor & Francis
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Abstract
Introduction: Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression of other β-lactamases is a serious public health threat. Carbapenemases belong to three main classes according to the Ambler classification: class A, class B, and class D. Areas covered: Carbapenemase-bearing pathogens are endemic in Latin America. In this review, we update the status of carbapenemases in Latin America and the Caribbean. Expert opinion: Understanding the current epidemiology of carbapenemases in Latin America and the Caribbean is of critical importance to improve infection control policies limiting the dissemination of multi-drug-resistant pathogens and in implementing appropriate antimicrobial therapy.
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Keywords
Acinetobacter baumannii, Carbapenem resistance, Carbapenem-resistant Enterobacterales (CRE), Carbapenemases, Carbapenems, Klebsiella pneumoniae, Pseudomonas aeruginosa