Antiproliferative activity of 3,5,7- trihydroxy -6- methoxy flavone obtained from chromolaena leivensis (Hieron) on cancer cell lines of breast, prostate, lung, colon and cervix

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dc.contributor.authorTorrenegra, Rubén Darío
dc.contributor.authorRodríguez, J.
dc.contributor.authorRODRIGUEZ AGUIRRE, OSCAR EDUARDO
dc.contributor.authorPalau, Victoria
dc.contributor.authorMendez-Callejas, Gina Marcela
dc.contributor.orcidRodríguez Aguirre, Oscar Eduardo [0000-0002-5934-0451]
dc.date.accessioned2020-07-15T22:34:03Z
dc.date.available2020-07-15T22:34:03Z
dc.date.issued2016
dc.description.abstractenglishThe flavone 3,5,7-trihydroxy-6-methoxyflavone was isolated from leaf extracts of Chromolaena leivensis (Hieron), commonly named plant of cancer. It was identified based on their physicochemical propierties and spectroscopic data. This compound presented a methoxylation at C6, this is uncommon in flavonoids and which may confer some specificity of its biological activity. The cytotoxic activity of this flavonoid was determined on PC3 (prostate), MDA- MB-231 (breast), HT29 (colon), SiHa (cervix) and A549 (lung) cancer cells, using MTT assay, to assess if the flavonoid contributes to the anticancer activity previously proposed for Chromolaena leivensis. The cytotoxic activity of the 3,5,7-trihydroxy-6- methoxy flavone was similar to that obtained for the flavonoid quercetin but was low compared with the positive control vincristine sulphate. The better value of the inhibitory concentration of fifty percent (IC50) 150 µM, was achieved on SiHa cell line, while the lower activity: 4008 µM, was obtained on HT29 cancer cell line. However, severe morphological changes were detected on cytoskeleton and nucleus of the SiHa cells detected by immunofluorescence microscopy analysis of cells exposed to the half of the IC50 concentration obtained for the flavonoid. Data indicate that the flavonoid contributes to the anticancer activity of the extracts of leaves from Chromolaena leivensis, and could broadening the spectrum of flavonoids activity against various types of cancer non hormone-dependent.eng
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1827-8620
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3515
dc.language.isoeng
dc.publisherSILAEspa
dc.publisher.journalPharmacologyonlinespa
dc.relation.ispartofseriesPharmacologyonline, 1827-8620, Vol, 2016, Nro.1 , 2016, p. 7-11spa
dc.relation.urihttps://pharmacologyonline.silae.it/files/archives/2016/vol1/PhOL_2016_1_A002_02_Torrenegra_7_11.pdf
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-04-30
dc.rights.localAcceso abiertospa
dc.subject.decsChromolaenaspa
dc.subject.decsPlantas medicinalesspa
dc.subject.decsCitotoxinasspa
dc.subject.keywordsCancer cellsspa
dc.subject.keywordsChromolaena leivensisspa
dc.subject.keywordsantiproliferative activityspa
dc.titleAntiproliferative activity of 3,5,7- trihydroxy -6- methoxy flavone obtained from chromolaena leivensis (Hieron) on cancer cell lines of breast, prostate, lung, colon and cervixspa
dc.title.translatedAntiproliferative activity of 3,5,7- trihydroxy -6- methoxy flavone obtained from chromolaena leivensis (Hieron) on cancer cell lines of breast, prostate, lung, colon and cervixspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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