A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

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dc.contributor.authorMunita, Jose M.
dc.contributor.authorTran, Truc T.
dc.contributor.authorDiaz, Lorena
dc.contributor.authorPanesso, Diana
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorMurray, Barbara E.
dc.contributor.authorArias, Cesar A.
dc.contributor.orcidPanesso, Diana [0000-0002-4049-9702]
dc.date.accessioned2020-07-17T17:53:32Z
dc.date.available2020-07-17T17:53:32Z
dc.date.issued2013
dc.description.abstractenglishThe genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/aac.00021-13
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3555
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 57, No. 6, 2013 p. 2831-2833spa
dc.relation.urihttps://aac.asm.org/content/57/6/2831.long
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2013-06
dc.rights.localAcceso abiertospa
dc.subject.decsEnterococcus faecalisspa
dc.subject.decsVancomicinaspa
dc.subject.decsDaptomicinaspa
dc.titleA liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalisspa
dc.title.translatedA liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant E}enterococcus faecalisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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