Cocristalización, una herramienta efectiva para mejorar la solubilidad y biodisponibilidad de los fármacos

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dc.contributor.advisorGonzález Amaya, Jhon Alex
dc.contributor.authorUrrea Rojas, Anamaría
dc.date.accessioned2024-05-15T00:22:11Z
dc.date.available2024-05-15T00:22:11Z
dc.date.issued2024-04
dc.description.abstractTeniendo en cuenta que una de las problemáticas que se presentan hoy en día en las industrias farmacéuticas es la baja biodisponibilidad de los fármacos debido a la baja solubilidad que presenta en el cuerpo humano, el presente documento pretende resaltar las características de la cocristalización como una posible solución a este inconveniente. Por consiguiente, se establece un marco referencial usando diferentes bases de datos con el cual se identifica las ventajas y desventajas de la cocristalización, en comparación con otras estrategias utilizadas para mejorar la biodisponibilidad de los fármacos. Los resultados muestran que la cocristalización ofrece ventajas significativas en la formulación de fármacos sólidos, permitiendo una mayor solubilidad y estabilidad. Se destaca que no solo aumenta, sino que también disminuye propiedades según las necesidades. Sin embargo, la complejidad en la selección del coformador y la producción a gran escala de las técnicas de síntesis son dificultades que se deben considerar. En conclusión, la cocristalización emerge como una alternativa prometedora para potenciar la solubilidad y estabilidad de los fármacos. No obstante, se necesita llevar a cabo una mayor cantidad de estudios para evaluar su viabilidad en la implementación a gran escala dentro de la industria farmacéutica en el futuro.
dc.description.abstractenglishConsidering that one of the problems that arise today in the pharmaceutical industries is the low bioavailability of drugs due to their low solubility in the human body, this paper aims to highlight the characteristics of cocrystallization as a possible solution to this drawback. Therefore, a referential framework is established using different databases with which the advantages and disadvantages of cocrystallization are identified, compared to other strategies used to improve the bioavailability of drugs. The results show that cocrystallization offers significant advantages in the formulation of solid drugs, allowing greater solubility and stability. It is highlighted that it not only increases, but also decreases properties as needed. However, the complexity in the selection of the coformer and the large-scale production of the synthesis techniques are difficulties to be considered. In conclusion, cocrystallization emerges as a promising alternative to enhance drug solubility and stability. Nevertheless, more studies need to be carried out to assess its feasibility for large-scale implementation within the pharmaceutical industry in the future.
dc.description.degreelevelPregradospa
dc.description.degreelevelQuímico Farmacéuticospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/12114
dc.language.isoes
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programQuímica Farmacéuticaspa
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dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCocristal
dc.subjectSolubilidad
dc.subjectFármaco
dc.subjectBiodisponibilidad
dc.subject.ddc615.19
dc.subject.keywordsCocrystal
dc.subject.keywordsSolubility
dc.subject.keywordsDrug
dc.subject.keywordsBioavailability
dc.titleCocristalización, una herramienta efectiva para mejorar la solubilidad y biodisponibilidad de los fármacos
dc.title.translatedCocrystallization, an effective tool to improve drug solubility and bioavailability
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Pregrado

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