Characteristics and long‐term outcomes of advanced pleural mesothelioma in Latin America (MeSO‐CLICaP)

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dc.contributor.authorRojas Puentes, Leonardo
dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.authorTrejo Rosales, Rogelio
dc.contributor.authorZatarain Barrón, Zyanya Lucia
dc.contributor.authorRamírez Tirado, Laura Alejandra
dc.contributor.authorRuíz-Patiño, Alejandro
dc.contributor.authorCampos Gómez, Saúl
dc.contributor.authorCorrales, Luis
dc.contributor.authorOblitas, George
dc.contributor.authorBacon, Ludwing
dc.contributor.authorMartín, Claudio
dc.contributor.authorCordeiro de Lima, Vladmir C.
dc.contributor.authorFreitas, Helano C.
dc.contributor.authorMas, Luis
dc.contributor.authorVargas Báez, Carlos Alberto
dc.contributor.authorCarranza, Hernán
dc.contributor.authorOtero, Jorge
dc.contributor.authorPérez, María Angelina
dc.contributor.authorGonzález, Lisde
dc.contributor.authorChirinos, Luis
dc.contributor.authorGranados, Sara T.
dc.contributor.authorRodríguez Ariza, July Katherine
dc.contributor.authorBáez, Renata
dc.contributor.authorRemolina Bonilla, Yuly Andrea
dc.contributor.authorNúñez Cerrillo, Gustavo
dc.contributor.authorArchila, Pilar
dc.contributor.authorCuello, Mauricio
dc.contributor.authorKarachaliou, Niki
dc.contributor.authorRosell, Rafael
dc.contributor.authorArrieta, Oscar
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.contributor.orcidVargas Báez, Carlos Alberto [0000-0002-6076-8260]
dc.contributor.orcidRojas Puentes, Leonardo [0000-0002-7865-5424]
dc.contributor.orcidRuíz-Patiño, Alejandro [0000-0003-1274-9273]
dc.contributor.orcidRodríguez Ariza, July Katherine [0000-0003-1168-595X]
dc.date.accessioned2019-11-14T12:59:55Z
dc.date.available2019-11-14T12:59:55Z
dc.date.issued2019
dc.description.abstractenglishBackground Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There is a lack of information about the clinical and pathological features related with survival in the Latin American population. Methods The MeSO‐CLICaP registry identified 302 patients with advanced MPM diagnosed and treated between January 2008 and March 2016. The Cox model was applied to determine the variables associated with survival. A random forest tree model was built to predict the response to first‐line chemotherapy among Latin American patients. Results The median age was 61.1 years (SD 10.6 years), 191 (63.2%) were men, 65.9% were ever smokers, and 38.7% had previous exposure to asbestos. A total of 237 (78.5%) had epithelioid tumors, and 188 (62.3%) and 114 (37.7%) cases had stage III or IV MPM, respectively. A total of 49 patients (16.2%) underwent pleurectomy, 57 (18.9%) received radiotherapy, and 279 patients received first‐line platinum‐based chemotherapy. The overall response rate to first‐line chemotherapy was 40.4%, progression‐free survival to first‐line treatment was 5.7 months (95% CI 4.9–6.5), and 63 (20.8%) patients had pemetrexed maintenance. The median overall survival was 16.8 months (95% CI 13.0–20.5), and multivariate analysis found that stage (P = 0.013), and pleurodesis (P = 0.048), were independent prognostic factors for first‐line overall survival. The model to predict response to first‐line chemotherapy obtained a 0.98 area under the curve, a sensitivity of 93%, and a specificity of 95% for detecting responders and non‐responders. Conclusion This study identifies factors associated with clinical benefit from chemotherapy among advanced MPM Latin American patients, emphasizing the impact of histology and the clinical benefit of chemotherapy on outcomes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/1759-7714.12967
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1759-7714
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1840
dc.language.isoeng
dc.publisherBlackwell Publishing Asia Ptyspa
dc.publisher.journalThoracic cancerspa
dc.relation.ispartofseriesThoracic cancer, 1759-7714, Vol. 10, Nro. 3, 2019, 508-518spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1111/1759-7714.12967
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf398
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.decsMesoteliomaspa
dc.subject.decsRadioterapiaspa
dc.subject.decsNeoplasias malignasspa
dc.subject.keywordsAsbestos exposurespa
dc.subject.keywordsChemotherapyspa
dc.subject.keywordsLatin Americaspa
dc.titleCharacteristics and long‐term outcomes of advanced pleural mesothelioma in Latin America (MeSO‐CLICaP)spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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