Principal findings of systematic reviews for the management of acute bronchiolitis in children

dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.contributor.authorSossa-Briceño, Monica P.
dc.date.accessioned2020-08-13T19:43:34Z
dc.date.available2020-08-13T19:43:34Z
dc.date.issued2015
dc.description.abstractenglishBronchiolitis is the most common cause of hospitalization among infants during the first 12 months of life, with high direct and indirect cost for health system and families. Different treatment approaches co-exist worldwide resulting in many drugs prescribed, without any proven benefit. Twenty systematic reviews of randomized clinical trials (SRCTs) on management of acute bronchiolitis in children were retrieved through 5 databases and their methodological quality was determined using an AMSTAR tool. Epinephrine showed impact only in short-term outcomes among outpatients (reduced admission at day 1 and improved the clinical score in the first 2 hours, compared to placebo) and inpatients (decreased length of stay (LOS) and improved saturation only in the first 2 hours, compared to nebulized salbutamol, but with high heterogeneity). Nebulized 3% saline among inpatients (but not in the emergency department setting) decreased hospital LOS. In small trials, exogenous surfactant among children may decrease the duration of mechanical ventilation and intensive care unit LOS and had favorable effects on oxygenation and CO2 elimination at 24 hrs. Although several SRCTs are currently available, only few treatments show clinically important improvements. Therefore, it is still difficult to prepare a well-established and accepted guideline for the treatment of acute bronchiolitis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.prrv.2014.11.004
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1526-0542
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3784
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalPaediatric Respiratory Reviewsspa
dc.relation.ispartofseriesPaediatric Respiratory Reviews, 1526-0542, Vol. 16, Nro. 4, 2015, p. 267-275spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1526054215000032?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-09
dc.rights.localAcceso abiertospa
dc.subject.keywordsAcute bronchiolitis managementspa
dc.subject.keywordsTreatmentspa
dc.subject.keywordsSystematic reviewspa
dc.subject.keywordsMethanalysisspa
dc.titlePrincipal findings of systematic reviews for the management of acute bronchiolitis in childrenspa
dc.title.translatedPrincipal findings of systematic reviews for the management of acute bronchiolitis in childrenspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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