Mechanism of action and resistance to daptomycin in Staphylococcus aureus and enterococci

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dc.contributor.authorMiller, William R.
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorArias, César A.
dc.date.accessioned2020-07-16T15:35:46Z
dc.date.available2020-07-16T15:35:46Z
dc.date.issued2016
dc.description.abstractenglishLipopeptides are natural product antibiotics that consist of a peptide core with a lipid tail with a diverse array of target organisms and mechanisms of action. Daptomycin (DAP) is an example of these compounds with specific activity against Gram-positive organisms. DAP has become increasingly important to combat infections caused by Gram-positive bacteria because of the presence of multidrug resistance in these organisms, particularly in methicillin- resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). However, emergence of resistance to DAP during therapy is a well-described phenomenon that threatens the clinical use of this antibiotic, limiting further the therapeutic options against both MRSA and VRE. Thiswork will review the historical aspects of the development of DAP, as well as the current knowledge on its mechanism of action and pathways to resistance in a clinically relevant context.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1101/cshperspect.a026997
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2157-1422
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3528
dc.language.isoeng
dc.publisherCold Spring Harbor Laboratory Pressspa
dc.publisher.journalCold spring harbor perspectives in medicinespa
dc.relation.ispartofseriesCold spring harbor perspectives in medicine, 2157-1422, Vol. 6, Nro. 11, 2016spa
dc.relation.urihttps://perspectivesinmedicine.cshlp.org/content/6/11/a026997
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-11
dc.rights.localAcceso abiertospa
dc.subject.decsDaptomicinaspa
dc.subject.decsAntiinfecciososspa
dc.subject.decsStaphylococcus aureus resistente a meticilinaspa
dc.titleMechanism of action and resistance to daptomycin in Staphylococcus aureus and enterococcispa
dc.title.translatedMechanism of action and resistance to daptomycin in Staphylococcus aureus and enterococcispa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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