Outbreak of CA-MRSA in patients with neuro-development disorders requiring ICU admission

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dc.contributor.authorMolano, D.
dc.contributor.authorVillabon, M.
dc.contributor.authorEscobar, J.
dc.contributor.authorVanegas, N.
dc.contributor.authorJordi, R.
dc.date.accessioned2022-03-02T21:21:37Z
dc.date.available2022-03-02T21:21:37Z
dc.date.issued2012
dc.description.abstractenglishINTRODUCTION. CA-MRSA in Latin America has become an emergent microorganism causing severe infections requiring ICU admission. This epidemic outbreak is especially present in a group of patients bearing characteristics associated with hospital care. OBJECTIVES. Description of the epidemiological characteristics related to genotyping, phenotyping, and management of a CA-MRSA outbreak in patients treated at an ICU in Bogota, Colombia. METHODS. Case studies and controls. RESULTS. Of 100 persons treated at a healthcare institution for neurodevelopmental diseases, 50 consulted to emergency departments between September 2008 and January 2009 with skin infections (n:15) arthritis (n:2) or pneumonia (n:1). In 15 of these patients CAMRSA was isolated, 53 % (8) in blood. Identified through genotyping such as SSCmec Ivc clone USA300, with lukF-PV/tukS-PV genes seq, sek and bsaB. 100 % were PVL positive. 10 (73 %) patients evidenced neuropsychiatric alterations with behavioral trauma such as coprophagy, shared use of hygiene elements, and recurrent skin lesions. 1 with pneumonia and 2 with skin infections required ICU admission. CA-MRSA was not documented in cultures of physicians, nurses, and therapists in charge of patient care at the institute. Decolonization of patients with CA-MRSA was conducted with nasal Mupirocin and Chlorhexidine baths for 7 days, and contact isolation was instaured. Global mortality was 20 % being lowest in the group that received empirical treatment with Vancomycin, compared to those that used Oxacillin-Clindamycin (33.3 vs. 66.6 %). CONCLUSIONS. USA300 is a potential cause of CA-MRSA outbreaks requiring ICU admission. REFERENCE(S). 1. Vandenesch F, et al. Emerg Infect Dis. 2003;9:978–84. 2. Campbell K, et al. J Clin Microbiol. 2004;50–4053. 3. Wagenlehner F, et al. J Hosp Infect. 2007;67:114–20.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00134-012-2683-0
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1432-1238
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/7076
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalIntensive Care Medicinespa
dc.relation.ispartofseriesIntensive Care Medicine, 1432-1238, Vol. 38, Supl., 2012, p. S49spa
dc.relation.urihttps://link.springer.com/article/10.1007/s00134-012-2683-0
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.titleOutbreak of CA-MRSA in patients with neuro-development disorders requiring ICU admissionspa
dc.title.translatedOutbreak of CA-MRSA in patients with neuro-development disorders requiring ICU admissionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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