An integrated approach for the valorization of mango seed kernel: Efficient extraction solvent selection, phytochemical profiling and antiproliferative activity assessment

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dc.contributor.authorBallesteros-Vivas, Diego
dc.contributor.authorÁlvarez-Rivera, Gerardo
dc.contributor.authorMorantes Medina, Sandra Johanna
dc.contributor.authorSánchez Camargo, Andrea del Pilar
dc.contributor.authorIbáñez, Elena
dc.contributor.authorParada Alfonso, Fabián
dc.contributor.authorCifuentes, Alejandro
dc.date.accessioned2020-03-14T14:39:58Z
dc.date.available2020-03-14T14:39:58Z
dc.date.issued2019
dc.description.abstractenglishA novel valorization strategy is proposed in this work for the sustainable utilization of a major mango processing waste (i.e. mango seed kernel, MSK), integrating green pressurized-liquid extraction (PLE), bioactive assays and comprehensive HRMS-based phytochemical characterization to obtain bioactive-rich fractions with high antioxidant capacity and antiproliferative activity against human colon cancer cells. Thus, a two steps PLE procedure was proposed to recover first the non-polar fraction (fatty acids and lipids) and second the polar fraction (polyphenols). Efficient selection of the most suitable solvent for the second PLE step (ethanol/ethyl acetate mixture) was based on the Hansen solubility parameters (HSP) approach. A comprehensive GC- and LC-Q-TOFMS/MS profiling analysis allowed the complete characterization of the lipidic and phenolic fractions obtained under optimal condition (100% EtOH at 150 °C), demonstrating the abundance of oleic and stearic acids, as well as bioactive xanthones, phenolic acids, flavonoids, gallate derivatives and gallotannins. The obtained MSKextract exhibited higher antiproliferative activity against human colon adenocarcinoma cell line HT-29 compared to traditional extraction procedures described in literature for MSK utilization (e.g. Soxhlet), demonstrating the great potential of the proposed valorization strategy as a valuable opportunity for mango processing industry to deliver a value-added product to the market with health promoting properties.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.foodres.2019.108616
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0963-9969
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2046
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalFood Research Internationalspa
dc.relation.ispartofseriesFood Research International, 0963-9969, Vol. 126, 2019, p.1-14spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0963996919304946
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf24
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.agrovocPropiedades fisicoquímicasspa
dc.subject.agrovocMangíferaspa
dc.subject.agrovocExtracción por presiónspa
dc.subject.keywordsFruit by-productsspa
dc.subject.keywordsHansen solubility parametersspa
dc.subject.keywordsPressurized-liquid extractionspa
dc.subject.keywordsHigh-resolution mass spectrometryspa
dc.subject.keywordsAntiproliferative activityspa
dc.titleAn integrated approach for the valorization of mango seed kernel: Efficient extraction solvent selection, phytochemical profiling and antiproliferative activity assessmentspa
dc.title.translatedAn integrated approach for the valorization of mango seed kernel: Efficient extraction solvent selection, phytochemical profiling and antiproliferative activity assessment
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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