Prevalencia de factores de riesgo asociados al cáncer de mama en el síndrome de cáncer de mama y ovario hereditario en pacientes latinoamericanas

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dc.contributor.advisorCastro Rojas, Carlos Andres
dc.contributor.advisorBeltran Lopez , Angela Patricia
dc.contributor.authorAmaya Rojas, Maria Paula
dc.contributor.authorDiaz Muñoz , Gustavo Alonso
dc.contributor.authorCastañeda Gomez, Angela Maria
dc.contributor.authorChaparro Daza, Juan Camilo
dc.contributor.authorAngulo Arriola, Juan Diego
dc.contributor.authorMontoya Ossa, Daniela
dc.contributor.orcidAmaya Rojas, Maria Paula [0000-0003-0753-4235]
dc.contributor.orcidDiaz Muñoz, Gustavo Alonso [0000-0002-9216-7873]
dc.contributor.orcidCastañeda Gomez, Angela Maria [0000-0003-3022-2352]
dc.contributor.orcidChaparro Daza, Juan Camilo [0000-00022425959x]
dc.contributor.orcidAngulo Arriola , Juan Diego [0000-0002-9668-1650]
dc.contributor.orcidMontoya Ossa,Daniela [0000-0002-2237-3970]
dc.date.accessioned2024-07-12T22:41:03Z
dc.date.available2024-07-12T22:41:03Z
dc.date.issued2024-04
dc.description.abstractEl síndrome de cáncer de mama y ovario hereditario (HBOC) es una condición relacionada con mutaciones en diferentes genes, especialmente en BRCA1 y BRCA2, que hace que sea más probable desarrollar ciertos tipos de cáncer como el de mama y ovario. Para el síndrome HBOC ya se han determinado factores genéticos, sin embargo, los factores no genéticos son limitados y desconocidos en América Latina. Este análisis post hoc del estudio LACAM tuvo como objetivo explorar la prevalencia de factores de riesgo de cáncer de mama en pacientes latinoamericanos con HBOC. Es un estudio prospectivo que incorpora 422 pacientes femeninas de diferentes centros clínicos de cinco países de América Latina. Todos los pacientes cumplieron los criterios de HBOC según la NCCN. El marco comprendió desde octubre de 2017 hasta diciembre de 2021. Se evaluaron características clínicas, patológicas y sociodemográficas. Los rangos de edad varían entre 36-71 años. El 88% de los pacientes nunca ha fumado; Los resultados del IMC arrojaron que el 56,6% tiene sobrepeso u obesidad; la edad media de la menarquia fue 12,8 ±1,8 años; El 75,8% de todos los participantes se encuentran en estado posmenopáusico. 353 mujeres han estado embarazadas, 316 de ellas (90%) tuvieron su primer (o único) embarazo ≤30 años; 319 (76,9%) mujeres amamantaron después del embarazo. 62,3% amamantaron durante ≤12 meses. 299 participantes no tienen ningún familiar de primer grado diagnosticado con cáncer de mama. Nuestros datos muestran una preponderancia de factores de riesgo no modificables para HBOC, como la edad. Además, también predominó un factor de riesgo modificable: IMC >25. Otros factores de riesgo descritos en la literatura mostraron variabilidad en los resultados de la muestra estudiada, pero no fueron prevalentes. El embarazo y la lactancia han demostrado ser factores protectores para la población de Los Ángeles.
dc.description.abstractenglishHereditary breast and ovarian cancer (HBOC) syndrome is a condition related to mutations in different genes, especially in BRCA1 and BRCA2, that makes it more likely to develop certain types of cancer such as breast and ovarian cancer. For HBOC syndrome, genetic factors have already been determined, nevertheless, non-genetic factors are limited and unknown in Latin America. This post hoc analyses of LACAM study aimed to explore the prevalence of risk factors of breast cancer in Latin American patients with HBOC. It is a prospective study that incorporates 422 female patients from different clinical centers of five countries of Latin America. All patients fulfilled the HBOC criteria according to the NCCN. The frametime included October 2017 until December 2021. Clinical, pathological and sociodemographic characteristics were evaluated. The age ranges vary between 36-71 years. 88% of the patients have never smoked; BMI results showed that 56,6% are overweight or obese; the age of menarche mean was 12.8 ±1.8 years; 75,8% of all participants are in a post-menopausal state. 353 women have been pregnant, 316 of them (90%) had their first (or only) pregnancy ≤30 years; 319 (76,9%) women breastfed after pregnancy. 62,3% breastfed for ≤12 months. 299 participants do not have a first degree family member diagnosed with breast cancer. Our data show a preponderance of unmodifiable risk factors for HBOC such as age. In addition, one modifiable risk factor BMI >25 was also predominant. Other risk factors described in the literature showed variability in outcomes for the studied sample, but were not prevalent. Pregnancy and breastfeeding have proven to be protective factors for the LA population.
dc.description.degreelevelPregradospa
dc.description.degreenameMédico Cirujanospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/12657
dc.language.isoen
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programMedicinaspa
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dc.rightsAttribution 4.0 Internationalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSíndrome de cáncer hereditario de mama y ovario
dc.subjectFactores de riesgo
dc.subjectAmérica Latina
dc.subjectEstudio LACAM
dc.subject.keywordsHereditary breast and ovarian cancer syndrome
dc.subject.keywordsRisk factors
dc.subject.keywordsLatin America
dc.subject.keywordsLACAM study
dc.subject.nlmW100
dc.titlePrevalencia de factores de riesgo asociados al cáncer de mama en el síndrome de cáncer de mama y ovario hereditario en pacientes latinoamericanas
dc.title.translatedPrevalence of risk factors associated with breast cancer in hereditary breast and ovarian cancer syndrome in Latin American patients
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Pregradospa

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