Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto

Vista sencilla de ítem
dc.contributor.advisorLafaurie, Gloria Ines
dc.contributor.advisorCastillo, Diana
dc.contributor.advisorDiaz Baez, David Augusto
dc.contributor.advisorGoretty Trujillo, Tammy
dc.contributor.authorPlata González, Julio Cesar
dc.date.accessioned2021-09-10T16:30:09Z
dc.date.available2021-09-10T16:30:09Z
dc.date.issued2017
dc.description.abstractLa Clorhexidina (CHX) es el agente antiplaca más usado para desinfección completa de la boca y en el control de la biopelícula dental en el periodo post operatorio, Sin embargo, algunos efectos colaterales han limitado su uso clínico. El ácido hipocloroso (HOCl) es una nueva sustancia antimicrobiana no antibiótica que ha mostrado alta susceptibilidad sobre bacterias asociada al biofilm dental. Comparar la efectividad clínica y la recolonización bacteriana de la placa subgingival a los 7, 21 y 90 días del HOCl 0.05%, 0,025% y CHX 0.2% y 0,12% durante el periodo post quirúrgico en pacientes con periodontitis crónica. Se realizó un estudio piloto, aleatorizado doble ciego donde se evaluaron 32 pacientes divididos aleatoriamente en dos grupos de 16 cada uno para recibir HOCl al 0,05% durante 7 días, seguido de HOCl al 0,025% o CHX 0.2% seguido de CHX al 0,12% hasta el día 21 después de cirugía periodontal con colgajo de Widman modificado en ausencia de higiene oral. Los pacientes fueron evaluados por índice de placa, índice gingival, profundidad de la bolsa y nivel de inserción y para recolonización bacteriana en placa subgingival por un período de 3 meses. Los datos fueron analizados por ANOVA de medidas repetidas y por modelos de efectos mixtos ajustados a tratamiento, tiempo e interacción tiempo-tratamiento. CHX mostró superioridad para la reducción de placa dental sobre HOCl (p<0.05). Para la reducción de la inflamación gingival, hemorragia al sondaje, reducción de las bolsas y la ganancia del nivel de inserción las diferencias no fueron significativas entre los grupos (p>0.05). En cuanto a la recolonización bacteriana ambos grupos se comportaron de manera similar para P. gingivalis, T. forsithya y T. denticola. A. antinomicentemcomitas y E. nodatum mostraron una rápida recolonización en la placa subgingival y los protocolos antiplaca no parecieron tener un efecto. HOCl muestra efectos similares a CHX en los índices clínicos y en la recolonización bacteriana sin embargo se observaron menos eventos adversos en el grupo del HOCl. El HOCl podría ser equivalente a la CHX como agente antiplaca en periodos post quirúrgicos.spa
dc.description.abstractenglishChlorhexidine (CHX) is the most used antiplaque agent for complete disinfection of the mouth and in the control of dental biofilm in the postoperative period. However, some side effects have limited its clinical use. Hypochlorous acid (HOCl) is a novel non-antibiotic antimicrobial substance that has shown high susceptibility to bacteria associated with dental biofilm. To compare the clinical effectiveness and bacterial recolonization of subgingival plaques at 7, 21 and 90 days of HOCl 0.05%, 0.025% and CHX 0.2% and 0.12% during the post-surgical period in patients with chronic periodontitis. A randomized, double-blind pilot study was conducted in which 32 patients were randomly divided into two groups of 16 each to receive 0.05% HOCl for 7 days, followed by 0.025% HOCl or CHX 0.2% followed of CHX to 0.12% until day 21 after periodontal surgery with modified Widman flap in the absence of oral hygiene. Patients were evaluated by plaque index, gingival index, pocket depth and insertion level and for bacterial recolonization in subgingival plaque for a period of 3 months. The data were analyzed by repeated-measures ANOVA and mixed effects models adjusted to treatment, time and time-treatment interaction. CHX showed superiority for reduction of dental plaque over HOCl (p <0.05). For the reduction of gingival inflammation, bleeding to probing, reduction of pockets and gain of insertion level the differences were not significant between the groups (p> 0.05). As for bacterial recolonization, both groups behaved similarly for P. gingivalis, T. forsithya and T. denticola. A. antinomicentemcomitas and E. nodatum showed rapid recolonization in the subgingival plaque and anti-plaque protocols did not appear to have an effect. HOCl shows similar effects to CHX in clinical indexes and in bacterial recolonization, however, fewer adverse events were observed in the HOCl group. HOCl could be equivalent to CHX as an antiplaque agent in post-surgical periods.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias Odontológicasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/6047
dc.language.isospa
dc.publisher.facultyFacultad de Odontologíaspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programMaestría en Ciencias Odontológicasspa
dc.relation.referencesAddy M., L. Willis, J. Moran. Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol Volume 10, Issue 1 February 1983 Pages 89–99spa
dc.relation.referencesAli, R.W.; Lie, T.; Skaug, N. Early effects of periodontal therapy on the detections frequency of four putative periodontal pathogens in adults. J. Periodontol., Chicago, v.63, p.540-547, 1995spa
dc.relation.referencesAllison DG. The biofilm matrix. Biofouling 2003: 19: 139–150.spa
dc.relation.referencesArmitage, G. C., Development of a classification system for periodontal diseases and conditions. Annals of Periodontology 4, 1–6, 1999spa
dc.relation.referencesArweiler NB, Boehnke N, Sculean A, Hellwig E, Auschill TM. Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4-day plaque regrowth study. J Clin Periodontol 2006; 33: 334–339spa
dc.relation.referencesArweiler NB. Auschill TM, Netuschil L, Brecx M, Reich E, Sculean A. Spatial distribution of vital and dead microorganisms in dental biofilms. Arch Oral Biol. 2001 May; 46(5):471-6.spa
dc.relation.referencesAxelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6 years. J Clin Periodontol. 1981 Jun; 8(3):239-48spa
dc.relation.referencesAxelsson, P., & Lindhe, J. (1981). The significance of maintenance care in the treatment of periodontal disease. Journal of clinical periodontology, 8(4), 281294spa
dc.relation.referencesAxelsson, P., Nyström, B. and Lindhe, J. (2004). The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Journal of Clinical Periodontology, 31: 749–757spa
dc.relation.referencesBadersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. III. Single versus repeated instrumentation. J Clin Periodontol. 1984 Feb; 11(2):114-24.spa
dc.relation.referencesBascones A. Periodoncia Clínica e Implantología Oral. Madrid: Ediciones; Avances Médico-Dentales 2001, pp 455-71spa
dc.relation.referencesBazzano G, Parodi R, Tabares S, Sembaj A. Evaluation of periodontal mechanical therapy in deep pockets: Clinical and bacteriological response. Rev. Clin. Periodoncia Implantol. Rehabil. Oral vol.5 no.3 Santiago dic. 2012spa
dc.relation.referencesBhat N, Mitra R, Oza S, Mantu VK, Bishnoi S, Gohil M, Gupta R. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. J Complement Integr Med. 2014 Jun; 11(2):129-37spa
dc.relation.referencesBirkedal_Hansen, H. (1993). Role of matrix metalloproteinases in human periodontal disease. Journal of Periodontology 64, 474-484spa
dc.relation.referencesBoutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. Periodontal pathogens: a quantitative comparison of anaerobic culture and realtime PCR. FEMS Immunol Med Microbiol. 2005 Aug 1; 45(2):191-9.spa
dc.relation.referencesBoutaga K., Arie Jan van Winkelhoff, Christina M. J. E. Vandenbroucke-Grauls & Paul H. M. Savelkoul. Comparison of Real-Time PCR and Culture for Detection of Porphyromonas gingivalis in Subgingival Plaque Samples. J Clin Microbiol. 2003 Nov; 41(11): 4950–4954.spa
dc.relation.referencesBowen WH. Nature of plaque. Oral Sci Review. 1976; 9:321 18. Bragd, L.; Daklen, J.; Wikstrom, M.; Slots, J. The capability of A. actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius to indicate progressive periodontitis; a retrospective study. J. Clin Periodont 1987; 14:95-98.spa
dc.relation.referencesBranda SS, Vik S, Friedman L, and Kolter R. Biofilms: the matrix revisited. Trends Microbiol2005: 13: 20–2.spa
dc.relation.referencesBrecx M., E. Brownsfone, L. MacDonald, S. Gelskey and M. Cheang. Efficacy of Listerine®, Meridol® and chlorhexidine mouthrinses as supplements to regular tooth-cleaning measures. J Clin Periodontol. March 1992, Volume 19, Issue 3, Pages 155–224spa
dc.relation.referencesBrecx, M., Netuschil, L., Reichert, B. and Schreil, G. (1990), Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. Journal of Clinical Periodontology, 17: 292–297spa
dc.relation.referencesBreslin PA, Tharp CD. Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses. 2001 Feb; 26(2):105-16.spa
dc.relation.referencesBrinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004; 303(5663):1532–1535.spa
dc.relation.referencesBusscher HJ, Norde W, Van Der Mei HC. Specific molecular recognition and nonspecific contributions to bacterial interaction forces. Appl Environ Microbiol 2008: 74: 2559–2564.spa
dc.relation.referencesCalderón J. L. Artículo de Revisión ÁCIDO HIPOCLOROSO (HOCl) “Una nueva alternativa en antisepsia y desinfección desarrollada en Colombia” Laboratorio Actual Año 26 No. 42, Septiembre de 2010.spa
dc.relation.references°Cao, C. F., Aeppli, D. M., Liljemark, W. F., Bloomquist, C. G., Bandt, C. L. & Wolff, L. F. (1990) Comparison of plaque microflora between Chinese and Caucasian population groups. Journal of Clinical Periodontology 17, 115–118.spa
dc.relation.referencesCarlen, A., Olsson, J. & Ramberg, P. (1996) Saliva mediated adherence, aggregation and prevalence in dental plaque of Streptococcus mutans, Streptococcus sanguis and Actinomyces spp, in young and elderly humans. Archives of Oral Biology 41, 1133–1140.spa
dc.relation.referencesCarlos JP, Wolfe MD, Zambon JJ, Kingman A. Periodontal disease in adolescents: some clinical and microbiologic correlates of attachment loss. J Dent Res. 1988; 67:1510-4.spa
dc.relation.referencesCarvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2004) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. Clinical results. Journal of Clinical Periodontology 31, 1070–1076spa
dc.relation.referencesCarvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2005) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. II. Microbiological results. Journal of Clinical Periodontology 32, 406–411.spa
dc.relation.referencesCasado JA, Merino J, Cid J, Subirá ML, Sánchez-Ibarrola A. Oxidantes y radicales libres en la Biomedicina. Rev Med Univ Navarra 1996; 34:165-74.spa
dc.relation.referencesCastillo DM, Castillo Y, Delgadillo NA, Neuta Y, Jola J, Calderón JL, Lafaurie GI. Viability and Effects on Bacterial Proteins by Oral Rinses with Hypochlorous Acid as Active Ingredient. Braz Dent J. 2015 Oct; 26(5):519-24spa
dc.relation.referencesCaton J: Consensus report: periodontal diagnosis and diagnostics aids: In Proceedings of the World Workshop in Clinical Periodontics, Chicago, 1989spa
dc.relation.referencesChoi YS, Kim YC, Jo AR et al. Porphyromonas gingivalis and dextran sulfate sodium induce periodontitis through the disruption of physical barriers in mice. Eur J Inflamm 2013; 11:419–431spa
dc.relation.referencesChong-Hou, S. & Hsein-Kun, L. The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. J. Dent. Sci. 4: 45-4, 2009.spa
dc.relation.referencesColombo, A. P., Haffajee, A. D., Dewhirst, F. E., Paster, B. J., Smith, C. M., Cugini, M. A. & Socransky, S. S. (1998) Clinical and microbiological features of refractory periodontitis subjects. Journal of Clinical Periodontology 25, 169–180.spa
dc.relation.referencesColombo, A. P., Teles, R. P., Torres, M. C., Rosalem, W., Mendes, M. C., Souto, R. M. & Uzeda, M. (2005) Effects of non-surgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results. Journal of Periodontology 76, 778–784.spa
dc.relation.referencesCortelli, J. R., Barbosa, M. D. S., & Westphal, M. A. (2008). Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research, 22, 44-54spa
dc.relation.referencesCortelli, J.R. et al. Detection of periodontal pathogens in oral mucous membranes of edentulous individuals. J. Periodontol., Chicago, v.79, n.10, p.1962-1965, Oct 2008spa
dc.relation.referencesCortelli, S. C., Cavallini, F., Alves, M. F. R., Bezerra, A. A., Queiroz, C. S., & Cortelli, J. R. (2009). Clinical and microbiological effects of an essential-oilcontaining mouth rinse applied in the “one-stage full-mouth disinfection” protocol—a randomized double-blinded preliminary study. Clinical oral investigations, 13(2), 189.spa
dc.relation.referencesCortelli, S.C. et al. Essential oils in one-stage full-mouth disinfection: doubleblind, randomized clinical trial of long-term clinical, microbial and salivary effects. J. Clin. Periodontol. Copenhagen, v.36, n.4, p.333-342, Apr. 2009spa
dc.relation.referencesCosterton, J.W., Lewandowski, Z., Caldwell, D.E., Korber, D.R. & Lappin_Scott, H.M. (1995). Microbial biofilms. Annual Reviews of Microbiology 49, 711-745spa
dc.relation.referencesCosterton, J.W., Stewart, P.S., and Greenberg, E.P. (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322.spa
dc.relation.referencesCousido MC et al., In vivo substantivity of 0.12% and 0.2% chlorhexidine mouthrinses on salivary bacteria. Clin Oral Invest (2010) 14:397–402spa
dc.relation.referencesCugini MA, Haffajee AD, Smith C, Kent RL, Socransky SS. The effect of scaling and root planning on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000; 27: 30–36.,spa
dc.relation.referencesCusimano, R.; Cusimano, M. & Cusimano, S. The genius of Alexis Carrel. Can. Med. Assoc. J., 131(9):1142-50, 1984.spa
dc.relation.referencesDahlén G, Manji F, Baelum V, Fejerskov O. Black-pigmented Bacteroides species and Actinobacillus actinomycetemcomitans in subgingival plaque of adult Kenyans. J Clin Periodontol. 1989; 16:305–10.spa
dc.relation.referencesDakic, A., Boillot, A., Colliot, C., Carra, M. C., Czernichow, S., & Bouchard, P. (2016). Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis. Frontiers in microbiology, 7.spa
dc.relation.referencesDanser, M.M. et al. Short-term effect of full-mouth extraction on periodontal pathogens colonizing the oral mucous membranes. J. Clin. Periodontol. Copenhagen, v.21, n.7, p.484-489, Aug. 1994spa
dc.relation.referencesDanser, M.M. et al. The effect of periodontal treatment on periodontal bacteria on the oral mucous membranes. J. Periodontol., Chicago, v.67, n.5, p.478-485, May 1996spa
dc.relation.referencesDashper SG, Ang CS, Veith PD, Mitchell HL, Lo AW, Seers CA, Walsh KA, Slakeski N, Chen D, Lissel JP, Butler CA, O’Brien-Simpson NM, Barr IG, Reynolds EC. Response of Porphyromonas gingivalis to heme limitation in continuous culture. J Bacteriol2009: 191: 1044–1055.spa
dc.relation.referencesDeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukocyte Biol 1996; 60:677-91.spa
dc.relation.referencesDentino A., Lee S., Mailhot J & Hefti AF. Principles of Periodontology. Periodontology 200 Vol 61, 2013, 16-53spa
dc.relation.referencesDeSouza R.F. Nascimento C. et al. Effects of the domestic use of a disclosing solution on the denture biofilm: a preliminary study. Volume 36, Issue 7, July 2009, Pages 491–497spa
dc.relation.referencesDuss C, Lang NP, Cosyn J, Persson GR. A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery. J Clin Periodontol 2010; 37: 988–997.spa
dc.relation.referencesEberhard J, Jervøe-Storm P-M, Needleman I, Worthington H, Jepsen S. Fullmouth treatment concepts for chronic periodontitis: a systematic review. J Clin Periodontol 2008; 35: 591–604spa
dc.relation.referencesEgelberg, J. (1965) Local effect of diet on plaque formation and development of gingivitis in dogs. Effect of hard and soft diets. Odontologisk Revy 6, 31–41.spa
dc.relation.referencesEldridge, K. R., Finnie, S. F., Stephens, J. A., Mauad, A. M., Munoz, C. A., & Kettering, J. D. (1998). Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent. The Journal of prosthetic dentistry, 80(6), 685-690spa
dc.relation.referencesErnst CP, Canbek K, Dillenburger A, Willershausen B. Clinical study on the effectiveness and side effects of hexetidine and chlorhexidine mouthrinses versus a negative control. Quintessence Int. 2005 Sep; 36(8):641-52.spa
dc.relation.referencesFalagas ME., Anastasios M. Kapaskelis, Vasilios D. Kouranos, Ourania K. Kakisi, Zoe Athanassa, Drosos E. Karageorgopoulos Outcome of Antimicrobial Therapy in Documented Biofilm-Associated Infections. July 2009, Volume 69, Issue 10, pp 1351–1361spa
dc.relation.referencesFang H, Han M, Li Q-L, Cao CY, Xia R, Zhang Z-H. Comparison of full-mouth disinfection and quadrant-wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta-analysis. J Periodont Res 2016; 51: 417–430spa
dc.relation.referencesFaveri M, Gursky LC, Feres M, Shibli JA, Salvador SL, de Figueiredo LC. Scaling and root planning and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Clin Periodontol 2006; 33: 819–828spa
dc.relation.referencesFeres, M., Haffajee, A. D., Gonçalves, C., Allard, K., Som, S., Smith, C., Goodson, M. & Socransky, S. S. (1999) Systemic doxycycline administration in the treatment of periodontal infections (I). Effect on the subgingival microbiota. Journal of Clinical Periodontology 26, 775–783.spa
dc.relation.referencesFine DH. Mouthrinses as adjuncts for plaque and gingivitis management. A status report for the American Journal of Dentistry. Am J Dent. 1988 Dec; 1(6):259-63.spa
dc.relation.referencesFine, D. H., Kaplan, J. B., Kachlany, S. C., & Schreiner, H. C. (2006). How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontology 2000, 42(1), 114-157.spa
dc.relation.referencesFlötra L, Gjermo P, Röla G & Waerhaug J. Side effects of chlorhexidine mouthwashes. Scand J Dent Res 1971; 79: 119-25.spa
dc.relation.referencesForng, R.-Y., Champagne, C., Simpson, W. and Genco, C. (2000), Oral Microbiology: Environmental cues and gene expression in Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Diseases, 6: 351–365.spa
dc.relation.referencesFrancetti L., Del Fabbro M, Testori T, Weinstein RL. Chlorhexidine spray versus chlorhexidine mouthwash in the control of dental plaque after periodontal surgery. J Clin Periodontol. 2000 Jun; 27(6):425-30.spa
dc.relation.referencesFrank, D.N., Zhu, W., Sartor, R.B & Li, E. Investigating the biological and clinical significance of human dysbioses. 2011; Trends in Microbiology 19, 427-434spa
dc.relation.referencesGarmyn, P., van Steenberghe, D. & Quirynen, M. (1998) Efficacy of plaque control in the maintenance of gingival health: plaque control in primary and secondary prevention. In: Lang, N.P., et al. Proceedings of the European Workshop on Mechanical Plaque Control. Chicago: Quintessence Publishing Co., Inc., pp. 107-120spa
dc.relation.referencesGenco R, Kornman K, Williams R. Informe de consenso. Las enfermedades periodontales: patogénesis y los factores microbianos. Ann Periodontol 1996; 1: 926 - 32.spa
dc.relation.referencesGjermo P. Chlorhexidine in dental practice. J Clin Periodontol.n1974; 1(3):14352.spa
dc.relation.referencesGrisi, D. C., Salvador, S. L., Figueiredo, L. C., Souza, S. L., Novaes, A. B. & Grisi, M. F. (2002) Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome. Journal of Clinical Periodontology 29, 875–881.spa
dc.relation.referencesGrossi SG., Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, Norderyd OM, Genco RJ. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol. 1994 Mar; 65(3):260-7.spa
dc.relation.referencesGunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. JADA. 2006; 137(12): 1649-57.spa
dc.relation.referencesGürgan CA., Eylem Zaim, Isxıl Bakirsoy, and Emel Soykan. Short-Term Side Effects of 0.2% Alcohol-Free Chlorhexidine Mouthrinse Used as an Adjunct to Non-Surgical Periodontal Treatment: A Double-Blind Clinical Study. J Periodontol 2006; 77:370-384.spa
dc.relation.referencesGusberti, F. A., Sampathkumar, P., Siegrist, B. E., & Lang, N. P. (1988). Microbiological and clinical effects of chlorhexidine digluconate and hydrogen peroxide mouthrinses on developing plaque and gingivitis. Journal of clinical periodontology, 15(1), 60-67spa
dc.relation.referencesHaffaje, A.D., Smith C., Torresyap, G. et al. (2001). Efficacy of manual and powered toothbrushes (II). Effect on microbiological parameters. Journal of Clinical Periodontology 28,947-54spa
dc.relation.referencesHaffajee AD et al. Controlling the Plaque Biofilm. Int Dent J 53 Suppl 3, 191-199. 2003spa
dc.relation.referencesHaffajee AD, Socransky SS, Patel MR, Song X. Microbial complexes in supragingival plaque. Oral Microbiol Immunol. 2008 Jun; 23(3):196-205.spa
dc.relation.referencesHaffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006; 42 219-58spa
dc.relation.referencesHaffajee AD1, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994 Jun; 5:78-111.spa
dc.relation.referencesHaffajee, A. D., Cugini, M. A., Dibart, S., Smith, C., Kent, R. L. Jr. & Socransky, S. S. (1997) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology 24, 324–334spa
dc.relation.referencesHall-Stoodley, L., Costerton, J.W., and Stoodley, P. (2004) Bacterial biofilms: from the environment to infectious disease. Nat Rev Microbiol 2: 95–108.spa
dc.relation.referencesHannig C, Hannig M, Attin T. Enzymes in the acquired enamel pellicle. Eur J Oral Sci 2005: 113: 2–13.spa
dc.relation.referencesHannig C, Hoch J, Becker K, et al: Lysozyme activity in the initially formed in situ pellicle. 2005; Arch Oral Biol 50:821spa
dc.relation.referencesHata S, Mayanagi H. Acid diffusion through extracellular polysaccharides produced by various mutants of Streptococcus mutans. Arch Oral Biol 2003: 48: 431–438.spa
dc.relation.referencesHill, D.A. & Artis, D. Intestinal bacteria and the regulation of immune cells homeostasis. 2010; Annual Review of Immunology 28, 623-667spa
dc.relation.referencesHornef MW, Wick MJ, Rhen M, Normark S. Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol2002: 3: 1033–1040.spa
dc.relation.referenceshttps://www.ncbi.nlm.nih.gov/tools/primer-blast/spa
dc.relation.referenceshttps://www.wipo.int/portal/index.html.es. revisado junio 2007spa
dc.relation.referencesJenkins S, Addy M, Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent. 1989; 11(6):12-6.spa
dc.relation.referencesJenkins S, Addy M, Wade W. The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol. 1988 Aug; 15(7):415-24.spa
dc.relation.referencesJervøe-Storm P-M, AlAhdab H, Semaan E, Fimmers R, Jepsen S. Microbiological outcomes of quadrant versus full-mouth root planning as monitored by real-time PCR. J Clin Periodontol 2007; 34: 156–163.spa
dc.relation.referencesJones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000. 1997; 15:55-62spa
dc.relation.referencesKaldahl WB, Kalkwarf KL, Patil K. A review of longitudinal studies that compared periodontal therapies. J Periodontol 1993; 64: 243–253.spa
dc.relation.referencesKirk, E.C. “The chemical bleaching of teeth” Dent Cosmos, 1989, Vol 31, 273-5spa
dc.relation.referencesKnöfler G, Purschwitz R, Jentsch H. Clinical evaluation of partial- and full-mouth scaling in the treatment of chronic periodontitis. J Periodontol 2007; 78: 2135–2142.)spa
dc.relation.referencesKolenbrander PE, Egland PG, Diaz PI, Palmer RJ Jr. Genome–genome interactions: bacterial communities in initial dental plaque. Trends Microbiol2005: 13: 11–15.spa
dc.relation.referencesKolenbrander PE. Oral microbial communities: biofilms, interactions, and genetic systems. Annu Rev Microbiol. 2000; 54:413-37.spa
dc.relation.referencesKolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79spa
dc.relation.referencesKolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79spa
dc.relation.referencesKolenbrander, PE, Palmer, R.J. Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev 2010; 8:471 – 480spa
dc.relation.referencesKumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S. Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. Int J Dent Hygiene 2013 Feb; 11 (1):35-40spa
dc.relation.referencesKuramitsu HK, He X, Lux R, Anderson MH, Shi W. Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev2007: 71: 653–670.spa
dc.relation.referencesLafaurie et al. Evaluation of the hypochlorous acid substantivity as anti-plaque agent. A randomized controlled trial. 2016spa
dc.relation.referencesLafaurie, GI.; Calderón, JL.; Zaror, C.; Millán, lV. & Castillo, DM. Ácido hipocloroso: una nueva alternativa como agente antimicrobiano y para la proliferación celular para uso en odontología. Int. J. Odontostomat., 9(3):475481, 2015.spa
dc.relation.referencesLafaurie, Gl, Aya MR, Arboleda S. Escalante A, Castillo DM, Millan LV, Calderon JL, Ruiz BN. Eficacia desinfectante del ácido hipocloroso sobre cepas con poder patogénico de cavidad oral. Rev Colombiana de Investigación en Odontologia 2009; 1:3-11spa
dc.relation.referencesLang NP, Tan WC, Kra ¨henmann MA, Zwahlen M. A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 2008; 35 (Suppl. 8): 8–21.spa
dc.relation.referencesLang, Niklaus P. & Brecx, M. C. (1986), Chlorhexidine digluconate–an agent for chemical plaque control and prevention of gingival inflammation. Journal of Periodontal Research, 21: 74–89.spa
dc.relation.referencesLaskaris, G. & Scully, C. (2003). Periodontal manifestations of local and systemic diseases: colour atlas and text.spa
dc.relation.referencesLevine JM. Dakin's solution: past, present, and future. Adv Skin Wound Care. 2013 Sep; 26(9):410-4spa
dc.relation.referencesLevy, R. M., Giannobile, W. V., Feres, M., Haffajee, A. D., Smith, C. & Socransky, S. S. (2002) The effect of apically repositioned flap surgery on clinical parameters and the composition of the subgingival microbiota: 12-month data. International Journal of Periodontics and Restorative Dentistry 22, 209–219spa
dc.relation.referencesLindhe J, Nyman S. The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease. J Clin Periodontol. 1975 Apr; 2(2):67-79.spa
dc.relation.referencesLöe H, Theilade E & Jensen S. Experimental gingivitis in man. J Periodontol 1965: 36: 177–187spa
dc.relation.referencesLorenz K., G. Bruhn, C. Heumann, L. Netuschil, M. Brecx, T. HoffmannLorenz. Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. J Clin Periodontol. Volume 33, Issue 8, August 2006 Pages 561–567spa
dc.relation.referencesMackler, B.F., Frostad, K. B., Robertson, P.B. & Levy, B.M. (1977). Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease. Journal of Periodontal Research 12, 37-45spa
dc.relation.referencesMagnusson I, Lindhe J, Yoneyama T, Liljenberg B Recolonization of a subgingival microbiota following scaling in deep pockets. J Clin Periodontol. 1984 Mar; 11(3):193-207. 119. Maia LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature. Journal of Dentistry, Volume 35, Issue 5, May 2007, Pages 359-37spa
dc.relation.referencesMainnemare A, Megarbane B, Soueidan A, Daniel A. Chapple IL. Hypochlorous acid and taurine-N-monochloramine in periodontal diseases. J Dent Res 2004; 83:823-31spa
dc.relation.referencesMandel, I. D. (1994) Antimicrobial mouthrinses: overview and update. Journal of the American Dental Association125, 2S–10S.spa
dc.relation.referencesMarinone MG, Savoldi E. Chlorhexidine and taste. Influence of mouthwashes concentration and of rinsing time. Minerva Stomatol. 2000 May; 49(5):221-6.spa
dc.relation.referencesMarsh PD, Percival RS. The oral microflora friend or foe? Can we decide? Int Dent J 2006: 56 (Suppl. 1): 233 – 239.spa
dc.relation.referencesMarsh, P. Dental plaque: biological significance of a biofilm and community lifestyle, Journal of Clinical Periodontology, 2005; 32 Suppl 6, 7-15spa
dc.relation.referencesMarsh, P.D. & Devine, D.A. How is the development of dental biofilms influenced by the host? Journal of Clinical Periodontology, 2011: 38 Suppl 11, 28-35spa
dc.relation.referencesMarsh, P.D. & Martin, M.V. Oral Microbiology, 5 th ed. Edinburgh: Churchill Livingstone. 2009.spa
dc.relation.referencesMckenna, S. M. & Davies, K. J. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem. J., 254(3):685-92, 1988spa
dc.relation.referencesMinisterio de Salud. Estudio Nacional de Salud Bucal ENSAB IV. Situación de Salud Bucal. Sistema Internacional de Clasificación de la Enfermedad Periodontal y Condiciones Asociadas. Bogotá (DC): Ministerio de Salud; 2014spa
dc.relation.referencesMombelli A, Gmur R, Gobbi C, Lang NP. Actinobacillus actinomycetemcomitans in adult periodontitis. I. Topographic distribution before and after treatment. J Periodontol 1994: 65: 820–826.spa
dc.relation.referencesMombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia⁄nigrescens, and Actinobacillus actinomycetemcomitans after mechanical therapy of periodontal disease. J Periodontol 2000: 71: 14–21.spa
dc.relation.referencesMorillo JM., et al. Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol. Vol 31, Issue 12 December 2004 Pages 1054–1060.spa
dc.relation.referencesNewman M.G. et al. Effect of 0.12% Chlorhexidine on Bacterial Recolonization Following Periodontal Surgery. J Periodontol 1989; 60:577-581spa
dc.relation.referencesNiklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 10. Infecciones periodontales; Ed. Medica Panamericana, Sixth edition 2017spa
dc.relation.referencesNiklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 36. Control mecánico de la placa supragingival; Ed. Medica Panamericana, Sixth edition 2017spa
dc.relation.referencesNobbs, A.H., Jenkinson, H.F. & Jakubovics, N.S. Stick to your gums: mechanisms of oral microbial adherence. 2011; Journal of Dental Research 90, 1271-1278spa
dc.relation.referencesNørskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. Nov., comb. nov., Aggregatibacter aphrophilus comb. Nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factorindependent isolates. Int J Syst Evol Microbiol. 2006 Sep; 56(Pt 9):2135-46.spa
dc.relation.referencesOliver, R. C., Holm-Pedersen, P. & Löe, H. (1969) The correlation between clinical scoring exudate measurements and microscopic evaluation of inflammation in the gingiva. Journal of Periodontal Research4, 160. Journal of periodontal Investigation 4: 160.spa
dc.relation.referencesOlsson H. Asklöw B. Johansson E. Slotte C. Rinsing with alcohol-free or alcohol based chlorhexidine solutions after periodontal surgery. A doubleblind, randomized, crossover, pilot study. Swed Dent J 2012; 36: 91-99spa
dc.relation.referencesOzan F, Sumer Z. Akin Z, Er, K, Ozan U & Deger O. (2007). Effects of mouthrinse containing propolis on oral microorganisms and human gingival fibroblast. European journal of dentistry, 195-201spa
dc.relation.referencesPage RC, Periodontal Therapy: prospects for the future. J Periodontol 1993; 64(8 Suppl): 744-53spa
dc.relation.referencesPage, R.C. & Schroeder, H.E. (1976). Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigations 34, 235-249spa
dc.relation.referencesPapapanou PN. Et al., Checkerboard Assessments of Periodontal Microbiota and Serum Antibody Responses: A Case-Control Study. Journal of Periodontology, June 2000, Vol. 71, No. 6, Pages 885-897spa
dc.relation.referencesPetrosian EA y col. Sodium hypochlorite in the treatment of suppurative wounds. Vestn Khir Im II Grek 1991; 146: 40-3spa
dc.relation.referencesPulcher JJ, Daniel JC. (1992). The effect of chlorhexidine digluconato on human fibroblasts in vitro. J Periodontol 63(6):526-532spa
dc.relation.referencesQuirynen M, Soers C, Desnyder M, Dekeyser C, Pauwels M, van Steenberghe D. A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy. J Clin Periodontol 2005; 32:390–400spa
dc.relation.referencesQuirynen N, Bollen CM, Vanderkerckhove BN, Dekeyser C, Papaioannou N, Eyssen H. Full versus partial mouth disinfection in the treatment of periodontal infectious: short term clinical and microbiological observation. J Dent Res 1995, 74:1459- 1467.spa
dc.relation.referencesQuirynen, M., Mongardini, C., De Soete, M., Pauwels, M., Coucke, W. & Van Eldere, J. (2000) The role of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis – long term clinical and microbiological observations. Journal of Clinical Periodontology 27, 578–589spa
dc.relation.referencesRamfjord SP, Caffesse RG, Morrison EC et al. Four modalities OD periodontal treatment compared over two years. J Periodontol 1981; 52: 655-62spa
dc.relation.referencesRams TE. Et al. Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol 1996, Vol 23, Issue 4, Pages 346–354.spa
dc.relation.referencesRenvert S. et al. Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis from periodontal pockets. J Clin Periodontol Volume 17, Issue 6 July 1990 Pages 345–350spa
dc.relation.referencesRenvert, S et al. The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers. J. Clin Periodontol., Chicago, v.25, n.2, p.153-157, Feb. 1998spa
dc.relation.referencesRenvert, S et al. Treatment of periodontal disease based on microbiological diagnosis. Relation between microbiological and clinical parameters during 5 years. J. Periodontol., Chicago, v.67, n.6, p.562-571, June 1996spa
dc.relation.referencesReynolds, J.J. & Meikle, M.C. (1997). Mechanisms of connective tissue matrix destruction in periodontitis. Periodontology 2000 14, 144-157spa
dc.relation.referencesRobson M.C., Payne W.G., Ko F., Mentis M., Donati G., Shafii S.M., Culverhouse S., Wang L., Khosrovi B., Najafi R., Cooper D.M., Bassiri M. Hypochlorous Acid as a Potential Wound Care Agent. Part II. Stabilized Hypochlorous Acid: It’s Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing. J Burns Wounds. 11:6, e6, 80-90.2007.spa
dc.relation.referencesRosen, H. & Klebanoff, S. J. Oxidation of Escherichia coli iron centers by themyeloperoxidase- mediated microbicidal system. J. Biol. Chem.,257(22):13731-5, 1982spa
dc.relation.referencesRound JL, Mazmanian SK. The gut microbiota shapes intestinal immuneresponses during health and disease. Nat Rev Immunol 9(5):313-323 (2009)spa
dc.relation.referencesRudney JD et al. Actinobacillus Actinomycetemcomitans, PorphyromonasGingivalis, and Tannerella Forsythensis Are Components of a PolymicrobialIntracellular Flora Within Human Buccal Cells. J Dent Res 84 (1), 59-63. 12005.spa
dc.relation.referencesRutala William A., Cole E., Thomann C., Weber David J. 1991. Stability andBactericidal Activity of Chlorine Solutions. Inf. Control Hosp. Epidem.19(5):323327.spa
dc.relation.referencesSam, C. H. & Lu, H. K. The role of hypochlorous acid as one of the reactiveoxygen species in periodontal disease. J. Dent. Sci., 4(2):45-54, 2009.spa
dc.relation.referencesSanz M, G. Newman, L. Anderson, W. Matoska, J. Otomo Corgel C. Saltini.Clinical Enhancement of Post-Periodontal Surgical Therapy by a 0.12%Chlorhexidine Gluconate Mouthrinse. Journal of Periodontology October1989, Vol. 60, No. 10, Pages 570-576spa
dc.relation.referencesSecuencia cirugía Widman modificado. Tomada de Periodontology 2000 Volumen 71, Issue 1, pages 128-139, 4 APR 2016spa
dc.relation.referencesSeki, M., Yamashita, Y., Shibata, Y., Torigoe, H., Tsuda, H. & Maeno, M. (2006) Effect of mixed mutans streptococci colonization on caries development. Oral Microbiology and Immunology 21, 47–52.spa
dc.relation.referencesSeymour G.J. & Greenspan, J.S. (1979). The phenotypic characterization oflymphocyte subpopulations in established human periodontal disease. Journalof Periodontal Research 14, 39-46spa
dc.relation.referencesSeymour, G.J., Powell, R.N. & Davies, W.I. (1979) Conversion of a stable Tcell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: a hypothesis. Journal of Clinical Periodontology 6, 267-277spa
dc.relation.referencesShapiro S, Giertsen E, Guggenheim B. An in vitro oral biofilm model forcomparing the efficacy of antimicrobial mouthrinses. Caries Res. 2002 MarApr; 36(2):93-100.spa
dc.relation.referencesSharma NC, Galustians HJ, Qaqish J, Charles CH, Vincent JW, McGuire JA: Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash. J Clin Periodontol 2003; 30: 590–594.spa
dc.relation.referencesShiloah, J, Patters, H. Dean, J. Bland P & Toledo G. The survival rate of Actinobacillus actinomicetemcomitans, Porphyromonas gingivalis and Bacteroides forsythus following 4 randomized treatment modalities. J Periodontol 1997; 68:720-728spa
dc.relation.referencesSiegrist B. E., Gusberti F. A., M. C. Brecx, H. P. Weber, N. P. Lang. Efficacy of supervised rinsing with chlorhexidine digluconate in comparison to phenolic and plant alkaloid compounds Volume 21, Issue s16, November 1986, Pages 60–73.spa
dc.relation.referencesSlots, J.; Rams, T.E. New views on periodontal microbiota in special patient categories. J. Clin. Periodontol. Copenhagen, v.18, n.6, p.411-420, July 1991spa
dc.relation.referencesSocransky SS, Haffajee AD Periodontal microbial ecology. Periodontol 2000. 2005; 38:135-87.spa
dc.relation.referencesSocransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb; 25(2):134-44.spa
dc.relation.referencesSocransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000, 2002: 28: 12–55.spa
dc.relation.referencesSocransky SS, Haffajee AD. Microbiología de la enfermedad periodontal. En: Lindhe J, Karring T, Lang NP, ed. Clinical Periodontology y la implantología dental. Copenhague: Munksgaard, 1997: 138 - 88.spa
dc.relation.referencesSocransky, S.S.; Haffajee, A.D. The bacterial etiology of destructive periodontal disease: current concepts. J. Periodontol., Chicago, v.63, n.4, p.322-331, Apr. 1992spa
dc.relation.referencesSreenivasan P, Gaffar A. Antiplaque biocides and bacterial resistance: A review. J Clin Periodontol 2002; 29(11):965-974.spa
dc.relation.referencesTatevossian A. The effects of heat inactivation, tortuosity, extracellular polyglucan and ion-exchange sites on the diffusion of [14C]-sucrose in human dental plaque residue in vitro. Arch Oral Biol1985: 30: 365–371.spa
dc.relation.referencesTeughels, W. et al. One-stage, full-mouth disinfection: fiction or reality? Periodontol. 2000, Munksgaard, v.50, n.1, p.39-51, June 2009spa
dc.relation.referencesTomás I, García-Caballero L, Cousido MC, Limeres J, Alvarez M, Diz P. Evaluation of chlorhexidine substantivity on salivary flora by epifluorescence microscopy. Oral Dis. 2009 Sep; 15(6):428-33.spa
dc.relation.referencesVacca-Smith AM, Venkitaraman AR, Schilling KM & Bowen WH. Characterization of glucosyltransferase of human saliva adsorbed onto hydroxyapatite surfaces. Caries Res. 1996; 30(5):354-60.spa
dc.relation.referencesVan Der Velden, U. et al. The habitat of periodontophatic micro-organisms. J. Clin Periodontol., Cophenagen, v.13, n.3, p.243-248, Mar. 1986spa
dc.relation.referencesVerkaik MJ et al. Oral Biofilm Models for Mechanical Plaque Removal. Clin Oral Investig 14 (4), 403-409. 2009 Jun 30.spa
dc.relation.referencesVissers MC, Winterbourn CC. Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid. Biochem J. 1995; 307(Pt 1):57–62.spa
dc.relation.referencesVroom JM, De Grauw KJ, Gerritsen HC, Bradshaw DJ, Marsh PD, Watson GK, Allison C, Birmingham JJ. Depth penetration and detection of pH gradients in biofilms using two-photon excitation microscopy. Appl Environ Microbiol1999: 65: 3502–3511.spa
dc.relation.referencesW.B. Hugo. & A.R. Longworth. Cytological aspects of the mode of action of chlorhexidine diacetate. Journal of Pharmacy and Pharmacology, Volume 17, Issue 1, January 1965, Pages 28–32spa
dc.relation.referencesWade, W.G. & Addy, M. (1989). In vitro activity of a chlorhexidine – containing mouthwash against subgingival bacteria. Journal of periodontology 60, 521523spa
dc.relation.referencesWalker, C. B. (1988), Microbiological effects of mouthrinses containing antimicrobials. Journal of Clinical Periodontology, 15: 499–505.spa
dc.relation.referencesWang L., Bassiri M., Najafi R., Najafi K., Yang J., Khos-rovi B., Hwong W., Barati E., Belisle B., Celeri C., Robson M.C. Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds.11: 65-79, 2007spa
dc.relation.referencesWatts A, Addy M. (2001), Tooth discoloration and staining: a review of the literature. Br Dent J. 2001 Mar 24; 190(6):309-16.spa
dc.relation.referencesWeiss SJ, Klein R, Slavika A. Chlorination of Taurine by Human Neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 1982 Sept; 70(3):598-607.spa
dc.relation.referencesWeiss SJ. Tissue Destruction by Neutrophils. The New England Journal of Medicine 1989 February 9; 320(6):365-376.spa
dc.relation.referencesWennström JL, Heijl L, Dahlén G, Gröndahl K. Periodic subgingival antimicrobial irrigation of periodontal pockets (I). Clinical observations. J Clin Periodontol. 1987 Oct; 14(9):541-50.spa
dc.relation.referencesWestfelt E, Nyman S, Lindhe J, Socransky S. Use of chlorhexidine as a plaque control measure following surgical treatment of periodontal disease. J Clin Periodontol. 1983 Jan; 10(1):22-36.spa
dc.relation.referencesWhittaker CJ, Klier CM, Kolenbrander PE. Mechanisms of adhesion by oral bacteria. Annu Rev Microbiol1996: 50: 513–552.spa
dc.relation.referencesWille, T et al. “rheological characteristics of thooth bleaching materials”. Journal of Oral Rehabilitation, 2000, Vol 27, 1060-1063spa
dc.relation.referencesWilson, M. Microbial Inhabitants of Humans. Their Ecology and Role in the Health and Disease. 2005; Cambridge: Cambridge University Press.spa
dc.relation.referencesWinkel EG, van Winkelhoff AJ, Timmerman MF, Vangsted T, van der Velden U. Effects of metronidazole in patients with “refractory” periodontitis associated with Bacteroides forsythus. J Clin Periodontol 1997; 24: 573-9spa
dc.relation.referencesXimenez-Fyvie, L. A., Haffajee, A. D. & Socransky, S. S. (2000b) Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. Journal of Clinical Periodontology 27, 722–732.spa
dc.relation.referencesYates R, Shearer BH, Huntington E and Addy M. A method to compare four mouthrinses. J Clin Periodontol 2002: 29: 519–523.spa
dc.relation.referencesYoshida A., Shiori Nagashima, Toshihiro Ansai, Masayo Tachibana, Hiroaki Kato, Hajime Watari, Tsugunori Notomi & Tadamichi Takehara. Loop Mediated Isothermal Amplification Method for Rapid Detection of the Periodontopathic Bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. J. Clin. Microbiol. May 2005 vol. 43 no. 5 24182424 200. Zijnge V, Meijer HF, Lie MA, Tromp JAH, Degener JE, Harmsen HJM, Abbas F: The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial. J Clin Periodontol 2010; 37: 518–525spa
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectClorhexidinaspa
dc.subjectHOClspa
dc.subjectAntiplacaspa
dc.subjectRecolonización bacterianaspa
dc.subject.decsÁcido hipoclorosospa
dc.subject.decsClorhexidinaspa
dc.subject.decsPeriodontitisspa
dc.subject.keywordsChlorhexidinespa
dc.subject.keywordsHOClspa
dc.subject.keywordsAntiplaquespa
dc.subject.keywordsBacterial recolonizationspa
dc.subject.nlmWU 100
dc.titleComparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio pilotospa
dc.type.coarhttps://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Maestríaspa

Archivos

Bloque original
Mostrando 1 - 2 de 2
Miniatura
Nombre:
Plata_González_Julio_Cesar_2017.pdf
Tamaño:
2.32 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
No hay miniatura disponible
Nombre:
Plata_González_Julio_Cesar_2017_Anexos.pdf
Tamaño:
1.23 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Maestría en Ciencias Odontológicas