Avances y desafíos en la fabricación de tabletas por impresión 3D

González Cristancho, Niccolo

Avances y desafíos en la fabricación de tabletas por impresión 3D

dc.contributor.advisor	Jiménez Cruz, Ronald Andrés
dc.contributor.author	González Cristancho, Niccolo
dc.date.accessioned	2024-11-20T16:35:21Z
dc.date.available	2024-11-20T16:35:21Z
dc.date.issued	2024-08
dc.description.abstract	Esta revisión examina los avances y desafíos en la fabricación de tabletas mediante impresión 3D, con un enfoque metodológico basado en el método PRISMA. La revisión de literatura se realizó utilizando bases de datos como PubMed, Scopus y Science Direct, con una búsqueda específica que arrojó 458 resultados iniciales. Tras eliminar duplicados y filtrar estudios según criterios de inclusión, se seleccionaron 51 artículos para análisis completo, de los cuales 30 estudios fueron incluidos en la revisión final. Los temas analizados incluyen el diseño de comprimidos con dosis y liberación controlada, IA aplicada, parámetros de proceso y diseño, impacto ambiental, impacto en el paciente, control de calidad, innovación en tecnología, integración de nanotecnología con impresión 3D, materiales y componente y ensayos in vivo. Los resultados destacan la capacidad de la impresión 3D para fabricar tabletas con geometrías complejas y una dosificación precisa, pero también revelan desafíos significativos como lo es en la tecnología, estabilidad, y regulación farmacéutica. También se evidencio que a menudo, resolver un desafío puede generar otros nuevos, lo que subraya la necesidad de continuar la investigación en esta área. En conclusión, aunque la impresión 3D ha mostrado avances prometedores en la fabricación de tabletas, se requiere un desarrollo continuo para superar los obstáculos existentes y facilitar su adopción más amplia en la industria farmacéutica.
dc.description.abstractenglish	This review examines the advances and challenges in tablet fabrication using 3D printing, with a methodological approach based on the PRISMA method. The literature review was conducted using databases such as PubMed, Scopus and Science Direct, with a targeted search yielding 458 initial results. After eliminating duplicates and filtering studies according to inclusion criteria, 51 articles were selected for full analysis, of which 30 studies were included in the final review. Topics analyzed included dose- and release-controlled tablet design, applied AI, process and design parameters, environmental impact, patient impact, quality control, technology innovation, integration of nanotechnology with 3D printing, materials and component, and in vivo testing. The results highlight the ability of 3D printing to manufacture tablets with complex geometries and precise dosing, but also reveal significant challenges such as in technology, stability, and pharmaceutical regulation. It was also evident that often, solving one challenge can generate new ones, underscoring the need for continued research in this area. In conclusion, although 3D printing has shown promising advances in tablet manufacturing, continued development is required to overcome existing hurdles and facilitate its wider adoption in the pharmaceutical industry.
dc.description.degreelevel	Pregrado	spa
dc.description.degreelevel	Químico Farmacéutico	spa
dc.format.mimetype	application/pdf
dc.identifier.instname	Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/13271
dc.language.iso	es
dc.publisher.faculty	Facultad de Ciencias	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Química Farmacéutica	spa
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dc.rights	Atribución-NoComercial-CompartirIgual 4.0 Internacional
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	https://purl.org/coar/access_right/c_abf2
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject	Impresión 3D
dc.subject	Tabletas
dc.subject	Innovación
dc.subject	Desarrollo
dc.subject	Industria farmacéutica
dc.subject	Manufactura
dc.subject.ddc	615.19
dc.subject.keywords	3D printing
dc.subject.keywords	Tablets
dc.subject.keywords	Innovation
dc.subject.keywords	Development
dc.subject.keywords	Pharmaceutical industry
dc.subject.keywords	Manufacturing
dc.title	Avances y desafíos en la fabricación de tabletas por impresión 3D
dc.title.translated	Advances and challenges in tablet manufacturing by 3D printing
dc.type.coar	https://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/bachelorThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Pregrado