Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit

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dc.contributor.authorPáez, María Teresa
dc.contributor.authorRodríguez, Diana Catalina
dc.contributor.authorLópez, Daniel Fernando
dc.contributor.authorCastañeda, Jorge Arturo
dc.contributor.authorGuerrero, Mario Francisco
dc.contributor.authorBuitrago Ramírez, Diana Marcela
dc.contributor.authorCuca, Luis Enrique
dc.contributor.orcidBuitrago Ramírez, Diana Marcela [0000-0001-6283-7656]
dc.date.accessioned2019-08-01T20:40:53Z
dc.date.available2019-08-01T20:40:53Z
dc.date.issued2013
dc.description.abstractenglishCroton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals): C. Schiedeanus (200 mg/kg/d, p.o), enalapril (reference, 10 mg/kg/d, p.o) and vehicle (control: olive oil 1 ml/kg/d, p.o). In addition, the blank group received only vehicle. The arterial blood pressure (BP) and heart rate (HR) were measured daily for six weeks. After sacrificing the animals, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10-6 M) and relaxant responses were achieved with cumulative concentrations of acetylcholine (ACh, 10-10 - 10-4 M). L-NAME increased the systolic arterial pressure in the control group, attaining mean values of 131 mm Hg at week 5, whereas the C. schiedeanus, enalapril and blank groups maintained blood pressure under 100 mm Hg. The capacity of PE to contract aortic rings was greater in the C. schiedeanus, enalapril and blank groups than in the control group (2157, 2005, 1910 and 1646 mg, respectively). The pEC50 values for ACh were as follows: C. Schiedeanus (6.89) >enalapril (6.39) > blank (5.68) > control (5.09). These results give support to C. Schiedeanus as a natural antihypertensive source.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1590/S1984-82502013000400027
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1471-2466
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1581
dc.language.isoeng
dc.publisherUniversidade de São Paulo, Faculdade de Ciências Farmacêuticasspa
dc.publisher.journalBrazilian Journal of Pharmaceutical Sciencesspa
dc.relation.ispartofseriesBrazilian Journal of Pharmaceutical Sciences, 2175-9790, Vol. 49, Num. 4, 2013, p.865-871spa
dc.relation.urihttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400027&lng=en&tlng=en
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf246
dc.rights.creativecommons2013
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.decsHipertensiónspa
dc.subject.decsPlantas medicinalesspa
dc.subject.decsExtractos vegetalesspa
dc.subject.keywordsCroton schiedeanus/pharmacognosyspa
dc.subject.keywordsAlmizelillo/use/hypertension preventionspa
dc.subject.keywordsNitric oxide/deficitspa
dc.titleCroton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficitspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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