Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer

Vista sencilla de ítem
dc.contributor.authorCastro-Rojas, Carlos A.
dc.contributor.authorEsparza-Mota, Antonio R.
dc.contributor.authorHernández-Cabrera, Francisco
dc.contributor.authorRomero-Díaz, Víktor Javier
dc.contributor.authorGonzález-Guerrero, Juan Francisco
dc.contributor.authorMaldonado-Garza, Héctor Jesús
dc.contributor.authorGonzález Sánchez, Irma
dc.contributor.authorBuenaventura-Cisneros, Sergio
dc.contributor.authorSánchez, Josefina Yoaly
dc.contributor.authorORTIZ-LOPEZ, ROCIO
dc.contributor.authorCamacho, Alberto
dc.contributor.authorBarboza-Quintana, Oralia
dc.contributor.authorROJAS-MARTINEZ, AUGUSTO
dc.date.accessioned2020-07-15T21:46:41Z
dc.date.available2020-07-15T21:46:41Z
dc.date.issued2017
dc.description.abstractenglishluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase (TYMS) gene is a potential marker of response and toxicity to fluoropyirimidines as this enzyme is the molecular target of these drugs. Our aim was to assess the association between variants of TYMS with response and toxicity to fluoropyrimidines in patients with CRC in independent retrospective and prospective studies. Variants namely rs45445694, rs183205964, rs2853542 and rs151264360 of TYMS were genotyped in 105 CRC patients and were evaluated to define their association with clinical response and toxicity to fluoropyrimidines. Additionally, the relationship between genotypes and tumor gene expression was analyzed by quantitative polymerase chain reaction. The 2R/2R (rs45445694) was associated with clinical response (p=0.05, odds ratio (OR)=3.45) and severe toxicity (p=0.0014, OR=5.21, from pooled data). Expression analysis in tumor tissues suggested a correlation between the 2R/2R genotype and low TYMS expression. The allele 2R (rs45445694) predicts severe toxicity and objective response in advanced CRC patients. In addition, the alleles G(rs2853542) and 6bp-(rs151264360) are independent predictors of response failure to chemotherapy. This is the first study made on a Latin American population that points out TYMS gene variants have predictive values for response and toxicity in patients with CRC treated with fluoropyrimidine-based chemotherapy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1515/dmpt-2017-0028
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2363-8915
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3507
dc.language.isoeng
dc.publisherWalter de Gruyterspa
dc.publisher.journalDrug metabolism and Personalized therapyspa
dc.relation.ispartofseriesDrug metabolism and Personalized therapy, 2363-8915, Vol. 34, Nro. 4, 2017, p. 209-218spa
dc.relation.urihttps://www.degruyter.com/view/journals/dmdi/32/4/article-p209.xml
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-12-20
dc.rights.localAcceso abiertospa
dc.subject.decsToxicidadspa
dc.subject.decsQuimioterapiaspa
dc.subject.decsNeoplasias colorrectalesspa
dc.subject.keywordsColorectal cancerspa
dc.subject.keywordsFluoropyrimidinesspa
dc.subject.keywordsObjective response ratespa
dc.titleThymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancerspa
dc.title.translatedThymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancerspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Carlos A. Castro-Rojas_2017.pdf
Tamaño:
237.77 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos