Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis

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dc.contributor.authorArias, Ivonne
dc.contributor.authorHerrera, Daniel
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorBello-Gualtero, Juan Manuel
dc.contributor.authorDe Avila, Juliette
dc.contributor.authorSalas-Cuestas, Fabián
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-09-21T21:58:10Z
dc.date.available2020-09-21T21:58:10Z
dc.date.issued2020
dc.description.abstractenglishObjective The evidence shows that previous infection with enteric pathogens is a requirement to develop pSpA. Based on our previous results, variances on regulation of SIgA might influence SpA activity; thus, the aim of this study was to correlate the levels of SIgA, IgA against some enteric bacteria, and IL-17, IL-21, and IL-6 with clinical features in a group of SpA patients. Methods Twenty-six pSpA, 20 nr-axSpA, 60 healthy volunteers (HV), and 34 patients with inflammatory bowel diseases (IBD) were included. All subjects were assessed to measure SIgA, total and specific IgA for enteric bacteria, and IL-17, IL-21, and IL-6 levels and clinical variables. For SpA patients, the diagnosis was verified 5 years after first evaluation to assess the risk of developing r-axSpA. Results SIgA levels were significantly higher in SpA patients than in HV and IBD (p < 0.0001 and p = 0.047, respectively). However, no differences for SIgA neither total IgA were found among the SpA subtypes (p = 0.624). Only IL-6 was higher in SpA than HV (p = 0.013). An inverse correlation was demonstrated for SIgA and BASFI (r: − 0.45; p = 0.003), BASDAI (r: − 0.39; p = 0.0123), ASDAS-CRP (r: − 0.37; p = 0.014), and ASDAS-ESR (r: − 0.45; p = 0.0021). There was no evidence of risk of developing r-axSpA in patients who previously showed high levels of serum antibodies. Conclusion The results show that pSpA as well as nr-axSpA share a similar SIgA-intestinal involvement independently of a previous infection. This suggests that serum SIgA increases are evidence of subclinical intestinal compromise which could have influence on disease activity but not in this progression.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s10067-020-05369-w
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1434-9949
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4131
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalClinical rheumatologyspa
dc.relation.ispartofseriesClinical rheumatology, 1434-9949, 2020spa
dc.relation.urihttps://link.springer.com/article/10.1007/s10067-020-05369-w
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-09-02
dc.rights.localAcceso abiertospa
dc.subject.keywordsASDASspa
dc.subject.keywordsBASDAIspa
dc.subject.keywordsIntestinal diseasespa
dc.subject.keywordsSecretory immunoglobulin A (SIgA)spa
dc.subject.keywordsSpondyloarthritisspa
dc.titleIncreasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritisspa
dc.title.translatedIncreasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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