Quantifying rotavirus kinetics in the REH tumor cell line using in vitro data

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dc.contributor.authorGonzalez-Parra, Gilberto
dc.contributor.authorDobrovolny, Hana
dc.contributor.authorAranda Lozano, Diego Fernando
dc.contributor.authorChen-Charpentier, Benito
dc.contributor.authorGuerrero Rojas, Rafael Antonio
dc.contributor.orcidGuerrero Rojas, Rafael Antonio [0000-0001-8755-3385]
dc.contributor.orcidGuerrero Rojas, Rafael Antonio [0000-0001-8755-3385]
dc.date.accessioned2020-07-10T14:55:31Z
dc.date.available2020-07-10T14:55:31Z
dc.date.issued2018
dc.description.abstractenglishGlobally, rotavirus is the most common cause of diarrhea in children younger than 5 years of age, however, a quantitative understanding of the infection dynamics is still lacking. In this paper, we present the first study to extract viral kinetic parameters for in vitro rotavirus infections in the REH cell tumor line. We use a mathematical model of viral kinetics to extract parameter values by fitting the model to data from rotavirus infection of REH cells. While accurate results for some of the parameters of the mathematical model were not achievable due to its global non-identifiability, we are able to quantify approximately the time course of the infection for the first time. We also find that the basic reproductive number of rotavirus, which gives the number of secondary infections from a single infected cell, is much greater than one. Quantifying the kinetics of rotavirus leads not only to a better understanding of the infection process, but also provides a method for quantitative comparison of kinetics of different strains or for quantifying the effectiveness of antiviral treatment.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.virusres.2017.09.023
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0168-1702
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3409
dc.language.isoeng
dc.language.isopor
dc.publisherElsevierspa
dc.publisher.journalVirus Researchspa
dc.relation.ispartofseriesVirus Research, 0168-1702, Vol. 244, 2018, p. 53-63spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0168170216307699?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2018-01-15
dc.rights.localAcceso abiertospa
dc.subject.decsAntígenosspa
dc.subject.decsLinfocitos Bspa
dc.subject.decsModelos biológicosspa
dc.subject.keywordsRotavirusspa
dc.subject.keywordsMathematical modelspa
dc.subject.keywordsOncolytic virusspa
dc.titleQuantifying rotavirus kinetics in the REH tumor cell line using in vitro dataspa
dc.title.translatedQuantifying rotavirus kinetics in the REH tumor cell line using in vitro dataspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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