Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma

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dc.contributor.authorBuendía, Jefferson Antonio
dc.contributor.authorAcuña-Cordero, Ranniery
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.date.accessioned2021-07-02T14:18:05Z
dc.date.available2021-07-02T14:18:05Z
dc.date.issued2021-06-03
dc.description.abstractenglishIntroduction Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and with results available within a few minutes. This study aimed to evaluate the cost-effectiveness of asthma management using fractional exhaled nitric oxide monitoring in patients between 4 and 18 years of age. Methods A Markov model was used to estimate the cost-utility of asthma management using fractional exhaled nitric oxide monitoring versus asthma management without using fractional exhaled nitric oxide monitoring (standard therapy) in patients between 4 and 18 years of age. Cost data were obtained from a retrospective study on asthma from a tertiary center, in Medellin, Colombia, while probabilities of the Markov model and utilities were obtained from the systematic review of published randomized clinical trials. The analysis was carried out from a societal perspective. Results The model showed that fractional exhaled nitric oxide monitoring was associated with a lower total cost than standard therapy (US $1333 vs. US $1452 average cost per patient) and higher QALYs (0.93 vs. 0.92 average per patient). The probability that fractional exhaled nitric oxide monitoring provides a more cost-effective use of resources compared with standard therapy exceeds 99% for all willingness-to-pay thresholds. Conclusion Asthma management using fractional exhaled nitric oxide monitoring was cost-effective for treating patients between 4 and 18 years of age with mild to moderate allergic asthma. Our study suggests evidence that could be used by decision-makers to improve clinical practice guidelines, but this should be replicated in different clinical settings.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12962-021-00287-3
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1478-7547
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5917
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalCost Effectiveness and Resource Allocationspa
dc.relation.ispartofseriesCost Effectiveness and Resource Allocation, 1478-7547, Vol. 19, No. 01, 2021, art. 33spa
dc.relation.urihttps://resource-allocation.biomedcentral.com/articles/10.1186/s12962-021-00287-3
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsHealth economicsspa
dc.subject.keywordsPublic healthspa
dc.subject.keywordsHealthcarespa
dc.titleCost utility of fractional exhaled nitric oxide monitoring for the management of children asthmaspa
dc.title.translatedCost utility of fractional exhaled nitric oxide monitoring for the management of children asthmaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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