Could Increase Levels of Dickkopf-1 Protein be Considered As a Potential Biomarker for Bone Resorption in Joint and Periodontal Disease in Patients with Early Rheumatoid Arthritis?
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2016
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Arthritis & Rheumatology, meeting abstracts, 2326-5205, Session Rheumatoid Arthritis – Clinical Aspects - Poster I: Clinical Characteristics/Presentation/Prognosis, 2016, 1886-87
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John Wiley & Sons
American College of Rheumatology
American College of Rheumatology
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Abstract
Periodontitis and rheumatoid arthritis (RA) are chronic destructive inflammatory diseases with significant worldwide prevalence. They are characterized by inflammatory lesions adjacent to bone destruction involving connective tissue and bone. Dickkopf-1 (DKK-1) is a major regulator of bone mass; however, their involvement in local bone resorption is largely unknown. The aim of this study was to assess the utility of DKK-1 levels in gingival crevicular fluid (GCF) and serum as a potential predictor of bone loss in periodontal disease and/or early RA.