Obtención de ácido levulínico, un promotor sintético de amplio uso en la industria farmacéutica, empleando ácido metanoico como catalizador

Guerrero Pinilla, Dana Valentina

Obtención de ácido levulínico, un promotor sintético de amplio uso en la industria farmacéutica, empleando ácido metanoico como catalizador

dc.contributor.advisor	Cortés Ortiz, William Giovanni
dc.contributor.advisor	Guerrero Fajardo, Carlos Alberto
dc.contributor.author	Guerrero Pinilla, Dana Valentina
dc.date.accessioned	2024-11-20T14:48:04Z
dc.date.available	2024-11-20T14:48:04Z
dc.date.issued	2025-10
dc.description.abstract	El ácido levulínico es un compuesto orgánico con un reconocido uso en la actualidad como molécula plataforma para la obtención de diversos productos químicos de gran interés en diferentes sectores industriales como la farmacéutica. Para la obtención del ácido se puede emplear la hidrólisis ácida, la cual es un proceso que emplea materias primas celulósicas empleando tratamientos ácidos, para favorecer la reacción. En este estudio, se desarrolló un diseño factorial para la evaluación de la influencia de la temperatura y el tiempo de reacción en el proceso de obtención de ácido levulínico a partir de glucosa, empleando ácido metanoico como catalizador. Los ensayos se llevaron a cabo a condiciones de 170 °C – 200 °C y 60 min – 120 min usando ácido metanoico al 10,0 % (v/v). Los resultados demostraron que a mayor temperatura (200 °C) y tiempo corto (60 min) se favorece la descomposición de glucosa a ácido levulínico. El uso de ácido metanoico como catalizador demuestra que proporciona un medio de reacción contribuyente en la formación del ácido levulínico con valores de rendimiento del 65,26 % y selectividad de 70,01 %.
dc.description.abstractenglish	Levulinic acid is an organic compound currently recognized for its use as a platform molecule for obtaining various chemicals of great interest in different industrial sectors, such as pharmaceuticals. Acid hydrolysis can be used to obtain levulinic acid, a process that employs cellulosic raw materials and acid treatments to promote the reaction. In this study, a factorial design was developed to evaluate the influence of temperature and reaction time in the process of obtaining levulinic acid from glucose, using methanoic acid as a catalyst. The experiments were carried out under conditions of 170°C – 200°C and 60 min – 120 min using 10.0% (v/v) methanoic acid. The results showed that higher temperatures (200°C) and shorter times (60 min) favor the decomposition of glucose to levulinic acid. The use of methanoic acid as a catalyst demonstrated that it provides a reaction medium that contributes to the formation of levulinic acid, with yields of 65.26% and selectivity of 70.01%.
dc.description.degreelevel	Pregrado	spa
dc.description.degreelevel	Químico Farmacéutico	spa
dc.format.mimetype	application/pdf
dc.identifier.instname	Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/13265
dc.language.iso	es
dc.publisher.faculty	Facultad de Ciencias	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Química Farmacéutica	spa
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dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	https://purl.org/coar/access_right/c_abf2
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Ácido levulínico
dc.subject	Glucosa
dc.subject	Ácido metanoi
dc.subject	Temperatura
dc.subject	Tiempos
dc.subject	Hidrólisis ácida
dc.subject.ddc	615.19
dc.subject.keywords	Levulinic acid
dc.subject.keywords	Glucose
dc.subject.keywords	Methanoic acid
dc.subject.keywords	Temperature
dc.subject.keywords	Times
dc.subject.keywords	Acid hydrolysi
dc.title	Obtención de ácido levulínico, un promotor sintético de amplio uso en la industria farmacéutica, empleando ácido metanoico como catalizador
dc.title.translated	Obtaining levulinic acid, a synthetic promoter widely used in the pharmaceutical industry, using methanoic acid as catalyst
dc.type.coar	https://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/bachelorThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Pregrado