Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer

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dc.contributor.authorArrieta, Oscar
dc.contributor.authorAviles‐Salas, Alejandro
dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.authorOrozco‐Morales, Mario
dc.contributor.authorHernández-Pedro, Norma
dc.contributor.authorCabrera-Miranda, Luis
dc.contributor.authorBarrios-Bernal, Pedro
dc.contributor.authorSoca-Chafre, Giovanny
dc.contributor.authorCruz-Rico, Graciela
dc.contributor.authorPeña-Torres, María de Lourdes
dc.contributor.authorMoncada-Claudio, Guadalupe
dc.contributor.authorRamirez-Tirado, Laura-Alejandra
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.date.accessioned2020-03-02T21:18:19Z
dc.date.available2020-03-02T21:18:19Z
dc.date.issued2020
dc.description.abstractenglishObjective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer. However, the expression and functional significance of CD47 in Non‐Small Cell Lung Cancer (NSCLC) has not been completely understood. Materials and Methods In this retrospective study, CD47 expression was immunohistochemically examined in tumor biopsies from 169 NSCLC patients. The association of CD47 levels (H‐score) with clinicopathological characteristics and survival outcomes was evaluated. Results CD47 protein was detected in 84% of patients with a median expression of 80% (0‐100). Tumor CD47 levels above 1% and 50% were found in 84% and 65.7% of patients, respectively. While, median CD47 staining index was 160 (0‐300). Patients were divided into two groups according to CD47 expression (high or low), using a cutoff value of 150. High CD47 expression was associated with wood smoke exposure (71.1% vs 28.9%, P = .013) and presence of EGFR (+) mutations (66.7% vs 33.3%, P = .04). Survival analysis carried out in the whole population did not show any association of CD47 expression and survival outcome. However, in patients with EGFR (+) mutations, CD47 expression was associated with higher progression‐free survival (PFS) (12.2 vs. 4.4 months, P = .032). When the survival analysis was performed according to CD47 levels (cut off value: 150), both, PFS and overall survival (OS) were shortened in patients with a high expression of CD47 (10.7 vs. NR, P = .156) and (29.2 vs. NR months P = .023), respectively. Conclusions CD47 overexpression is not a prognostic factor for PFS and OS in NSCLC patients. However, the presence of EGFR mutations and high expression of CD47 were associated with shortened PFS and OS. Coexpression of these markers represents a potential biomarker and characterizes a therapeutic niche for lung cancer.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/cam4.2882
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2045-7634
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1966
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalCancer Medicinespa
dc.relation.ispartofseriesCancer Medicine, 2045-7634, 2020, p. 1-13spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/cam4.2882
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf18
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsGlicoproteínas de membranaspa
dc.subject.decsInmunidad innataspa
dc.subject.decsAdenocarcinoma del pulmónspa
dc.subject.keywordsImmune checkpointspa
dc.subject.keywordsLung adenocarcinomaspa
dc.subject.keywordsPhagocytosisspa
dc.titleAssociation between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancerspa
dc.title.translatedAssociation between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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