Comprehensive genomic profiling of combined small cell lung cancer

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dc.contributor.authorZhang, Jing
dc.contributor.authorZhang, Liping
dc.contributor.authorLuo, Jie
dc.contributor.authorGe, Tao
dc.contributor.authorFan, Pengyu
dc.contributor.authorSun, Liangdong
dc.contributor.authorHou, Likun
dc.contributor.authorLi, Junqiang
dc.contributor.authorYu, Huansha
dc.contributor.authorWu, Chunxiao
dc.contributor.authorZhu, Yuming
dc.contributor.authorWu, Chunyan
dc.contributor.authorJiang, Gening
dc.contributor.authorTroncone, Giancarlo
dc.contributor.authorMalhotra, Jyoti
dc.contributor.authorOkuda, Katsuhiro
dc.contributor.authorSantarpia, Mariacarmela
dc.contributor.authorZamarchi, Rita
dc.contributor.authorGoto, Taichiro
dc.contributor.authorCardona, Andrés F.
dc.contributor.authorXu, Jianfang
dc.contributor.authorChen, Qiankun
dc.contributor.authorZhang, Zhonghong
dc.contributor.authorZhang, Peng
dc.date.accessioned2022-08-08T23:33:35Z
dc.date.available2022-08-08T23:33:35Z
dc.date.issued2021
dc.description.abstractenglishBackground: Combined small cell lung cancer (CSCLC) is an uncommon and heterogeneous subtype of small cell lung cancer (SCLC). However, there is limited data concerning the different molecular changes and clinical features in CSCLC compared to pure SCLC. Methods: The clinical and pathological characteristics of pure SCLC and CSCLC patients were analyzed. Immunohistochemistry and microdissection were performed to isolate the CSCLC components. Further molecular analysis was carried out by next-generation sequencing (NGS) in 12 CSCLC and 30 pure SCLC. Results: There were no significant differences in clinical features between CSCLC and pure SCLC. Overall survival (OS) of CSCLC patients was worse than pure SCLC (P=0.005). NGS results indicated that TP53 and RB1 were the most frequently mutated genes in both CSCLC (83.33% and 66.67%) and pure SCLC (80.00% and 63.33%) groups. However, less than 10% common mutations were found in both CSCLC and pure SCLC. When analyzing the data of SCLC and non-small cell lung cancer (NSCLC) components of CSCLC, more than 50% common mutations, and identical genes with mutations were detected. Moreover, there were also common biological processes and signaling pathways identified in CSCLC and pure SCLC, in addition to SCLC and NSCLC components. Conclusions: There were no significant differences in terms of clinical features between CSCLC and pure SCLC. However, the prognosis for CSCLC was worse than pure SCLC. NGS analysis suggested that CSCLC components might derive from the same pluripotent single clone with common initial molecular alterations and subsequent acquisitions of other genetic mutations.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.21037/TLCR-20-1099
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2226-4477
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/8686
dc.language.isoeng
dc.publisherAME Publishing Companyspa
dc.publisher.journalTranslational Lung Cancer Researchspa
dc.relation.ispartofseriesTranslational Lung Cancer Research, 2226-4477, Vol 10, No 2, February, 2021spa
dc.relation.urihttps://tlcr.amegroups.com/article/view/48244/html
dc.rights.accessrightshttps://purl.org/coar/access_right/c_14cb
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.localAcceso cerradospa
dc.subjectCáncer de pulmón de células pequeñas combinado (CPCP)spa
dc.subjectCáncer de pulmón de células pequeñas (CPCP)spa
dc.subjectPerfiles genómicos completosspa
dc.subjectSecuenciación genética dirigidaspa
dc.subject.keywordsCombined small cell lung cancer (CSCLC)spa
dc.subject.keywordsSmall cell lung cancer (SCLC)spa
dc.subject.keywordsComprehensive genomic profilingspa
dc.subject.keywordsTargeted gene sequencingspa
dc.titleComprehensive genomic profiling of combined small cell lung cancerspa
dc.title.translatedComprehensive genomic profiling of combined small cell lung cancerspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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