Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)

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dc.contributor.authorMartín, Claudio
dc.contributor.authorEnrico, Diego
dc.contributor.authorMas, Luis
dc.contributor.authorPatane, Ana Karina
dc.contributor.authorArrieta, Oscar
dc.contributor.authorSoria, Tannia
dc.contributor.authorCardona, Andrés F.
dc.contributor.authorAlejandro, Ruiz Patiño
dc.contributor.authorRuiz, Rossana
dc.contributor.authorRioja, Patricia
dc.contributor.authorLozano, Sophia
dc.contributor.authorZatarain Barrón, Zyanya Lucia
dc.contributor.authorBarrón, Feliciano
dc.contributor.authorPuparelli, Carmen
dc.contributor.authorTsou, Florencia
dc.contributor.authorCorassa, Marcelo P.
dc.contributor.authorFreitas, Helano C.
dc.contributor.authorCordeiro de Lima, Vladmir Cláudio
dc.contributor.authorRojas, Leonardo
dc.contributor.authorOrdóñez Reyes, Camila
dc.contributor.authorCorrales, Luis Alejandro
dc.contributor.authorSotelo, Carolina
dc.contributor.authorRodríguez, July
dc.contributor.authorRicaurte, Luisa
dc.contributor.authorAvila, Jenny
dc.contributor.authorArchila, Pilar
dc.contributor.authorRosell, Rafael
dc.contributor.authorCuello, Mauricio
dc.contributor.authorRemon, Jordi
dc.contributor.authorCLICaP
dc.contributor.orcidMartín, Claudio [0000-0003-4135-7332]
dc.contributor.orcidMas, Luis [0000-0002-2323-9271]
dc.contributor.orcidCardona, Andrés F. [0000-0003-3525-4126]
dc.contributor.orcidAlejandro, Ruiz Patiño [0000-0003-1274-9273]
dc.contributor.orcidRioja, Patricia [0000-0003-3141-7418]
dc.date.accessioned2022-02-02T20:26:07Z
dc.date.available2022-02-02T20:26:07Z
dc.date.issued2021
dc.description.abstractenglishBackground: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologically proven thymomas diagnosed between 1997 and 2018. Demographics, linicopathological characteristics and therapeutic outcomes were collected locallyand analyzed in a centralized manner.Results: A total of 135 patients were included. Median age at diagnos is was 53 yearsold (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG perfor-mance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic diseaseat diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgerywas performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival(OS) at five-years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB,respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase(LDH) (≤373 IU/L) at baseline and myasthenia gravis concur rence showed signifi-cantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, highLDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baselineand not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) weresignificantly associated with increased risk of death.Conclusions: Our data provides the largest insight into the clinical characteristics andoutcomes of patients with thymomas in Latin America. Survival in patients withthymomas continues to be very favorable, especially when subjected to adequatelocal control.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1759-7714
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/6715
dc.language.isoeng
dc.publisherChina Lung Oncology Groupspa
dc.publisherJohn Wiley & Sons Australia, Ltdspa
dc.publisher.journalThoracic Cancerspa
dc.relation.ispartofseriesThoracic Cancer, 1759-7714, May, 12(9),2021,1328-1335spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13901
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAmerica latinaspa
dc.subjectOncologia medicaspa
dc.subjectTimomaspa
dc.subject.keywordsCohort studiesspa
dc.subject.keywordsLatin Americaspa
dc.subject.keywordsMedical oncologyspa
dc.subject.keywordsThymomaspa
dc.titleCharacteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)spa
dc.title.translatedCharacteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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