The relationship between inflammation and remodeling in childhood asthma: A systematic review

Vista sencilla de Ă­tem
dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorSaglani, Sejal
dc.contributor.authorRodriguez‐Martinez, Carlos E.
dc.contributor.authorOyarzun, Maria A.
dc.contributor.authorFleming, Louis
dc.contributor.authorBush, Andrew
dc.date.accessioned2020-05-18T11:08:10Z
dc.date.available2020-05-18T11:08:10Z
dc.date.issued2018
dc.description.abstractenglishObjectives We aimed to perform a systematic review of all studies with direct measurements of both airway inflammation and remodeling in the subgroup of children with repeated wheezing and/or persistent asthma severe enough to warrant bronchoscopy, to address whether airway inflammation precedes remodeling or is a parallel process, and also to assess the impact of remodeling on lung function. Methods Four databases were searched up to June 2017. Two independent reviewers screened the literature and extracted relevant data. Results We found 526 references, and 39 studies (2390 children under 18 years old) were included. Airway inflammation (eosinophilic/neutrophilic) and remodeling were not present in wheezers at a mean age of 12 months, but in older pre‐school children (mean 2.5 years), remodeling (mainly increased reticular basement membrane [RBM] thickness and increased area of airway smooth muscle) and also airway eosinophilia was reported. This was worse in school‐age children. RBM thickness was similar in atopic and non‐atopic preschool wheezers. Airway remodeling was correlated with lung function in seven studies, with FeNO in three, and with HRCT‐scan in one. Eosinophilic inflammation was not seen in patients without remodeling. There were no invasive longitudinal or intervention studies. Conclusion The relationship between inflammation and remodeling in children cannot be determined. Failure to demonstrate eosinophilic inflammation in the absence of remodeling is contrary to the hypothesis that inflammation causes these changes. We need reliable, non‐invasive markers of remodeling in particular if this is to be addressed.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/ppul.23968
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1099-0496
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2943
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalPediatric pulmonologyspa
dc.relation.ispartofseriesPediatric pulmonology, 1099-0496, Vol 53, Num 6, 2018, pag 824-835spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.23968
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsEstado asmĂĄticospa
dc.subject.decsRemodelaciĂłn de las vĂ­as aĂŠreas (Respiratorias)spa
dc.subject.decsLavado broncoalveolarspa
dc.subject.keywordsAirway biopsyspa
dc.subject.keywordsAirway inflammationspa
dc.subject.keywordsAirway remodelingspa
dc.subject.keywordsAsthmaspa
dc.subject.keywordsBronchial biopsyspa
dc.subject.keywordsBronchoalveolar lavagespa
dc.subject.keywordsChildrenspa
dc.subject.keywordsInfantsspa
dc.subject.keywordsWheezingspa
dc.titleThe relationship between inflammation and remodeling in childhood asthma: A systematic reviewspa
dc.title.translatedThe relationship between inflammation and remodeling in childhood asthma: A systematic reviewspa
dc.typearticlespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartĂ­culospa

Archivos

Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
TamaĂąo:
1.71 KB
Formato:
Item-specific license agreed upon to submission
DescripciĂłn:
Descargar

Colecciones

ArtĂ­culos