Expression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndrome

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dc.contributor.authorJ. Martínez, Pinilla
dc.contributor.authorAyala-Ramírez, P.
dc.contributor.authorGarcía-Robles, R.
dc.contributor.authorOlaya-C, M.
dc.contributor.authorBermúdez, M.
dc.date.accessioned2020-08-06T20:25:03Z
dc.date.available2020-08-06T20:25:03Z
dc.date.issued2015
dc.description.abstractenglishDown syndrome is the most frequent aneuploidy in live births, with an overall frequency of 1/600-700 births. The overexpression of cystathionine β-synthase is thought to participate in the presentation of some phenotypes observed in Down syndrome. OBJECTIVE: The aim of this study was to compare the expression levels of cystathionine β-synthase and histopathological observations from placentas of infants with Down syndrome and healthy newborns. MATERIALS AND METHODS: Six placentas of fetuses/infants with Down syndrome and sixteen placentas of healthy fetuses were studied. Cystathionine β-synthase mRNA and protein expression were performed by real-time PCR and immunohistochemistry, respectively. RESULTS: We observed an increase in cystathionine β-synthase mRNA expression (p = 0.0465) and protein levels (p = 0.009) in placentas of fetus/infants with Down syndrome compared with controls. Significantly more circinate edges (p = 0.0007) and trophoblast inclusions (p = 0.0037) were observed in the group with Down syndrome compared with control group. CONCLUSION: The results demonstrate overexpression of cystathionine β-synthase mRNA and protein in placentas of fetuses/infants with trisomy 21. Further histological abnormalities were found in placentas of patients with Down syndrome, suggesting an alteration in the development of placenta.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3233/NPM-15814092
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1878-4429
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3726
dc.language.isoeng
dc.publisherIOS Pressspa
dc.publisher.journalJournal of neonatal-perinatal medicinespa
dc.relation.ispartofseriesJournal of neonatal-perinatal medicine, 1878-4429, Vol. 8, Nro. 2 2015, p. 77-84spa
dc.relation.urihttps://content.iospress.com/articles/journal-of-neonatal-perinatal-medicine/npm814092
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015
dc.rights.localAcceso abiertospa
dc.subject.keywordsCystathionine β-synthasespa
dc.subject.keywordsDown syndromespa
dc.subject.keywordsPlacentaspa
dc.titleExpression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndromespa
dc.title.translatedExpression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndromespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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