Periodontal disease in individuals with a genetic risk of developing arthritis and early rheumatoid arthritis: A cross-sectional study

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dc.contributor.authorBello‐Gualtero, Juan M.
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorHoyos, Lida X.
dc.contributor.authorCastillo Sierra, Diana Marcela
dc.contributor.authorDe Avila, Juliette
dc.contributor.authorMunévar Niño, Juan Carlos
dc.contributor.authorUnriza-Puin, Sonia R.
dc.contributor.authorLondoño, John
dc.contributor.authorValle‐Oñate, Rafael
dc.contributor.authorRomero‐Sánchez, Consuelo
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidMunévar Niño, Juan Carlos [0000-0002-8482-2962]
dc.date.accessioned2020-11-25T21:24:14Z
dc.date.available2020-11-25T21:24:14Z
dc.date.issued2016
dc.description.abstractenglishRecent consensus emphasizes the importance of studying individuals at risk for rheumatoid arthritis (pre‐RA) and those with early RA (eRA). Periodontal tissues have been recently evaluated, but these studies are limited. To evaluate the periodontal condition, immunoglobulin (Ig)G subclasses against Porphyromonas gingivalis in individuals with pre‐RA and eRA were compared with controls to establish an association between periodontal infection markers and rheumatic activity. Rheumatologic and periodontal condition was evaluated in 119 individuals with pre‐RA, 48 patients with eRA, and matched controls. P. gingivalis IgG1 and IgG2 were analyzed. C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor, anticitrullinated protein antibodies (ACPAs), and RA activity were measured. The groups were compared with McNemar test and paired t‐test. Conditional logistic regression was performed for pre‐RA confounders, and χ2 test was used to evaluate periodontal variables and RA activity indices. Pre‐RA individuals showed significantly higher levels of plaque index (P = 0.01) and bleeding on probing (P = 0.03) and higher severity of periodontal disease (P = 0.02). Periodontitis was associated with pre‐RA (odds ratio, 3.39; 95% confidence interval, 1.64 to 7.01) but not with eRA. In pre‐RA, P. gingivalis–specific IgG2 was associated with ACPAs (P = 0.049) and disease severity visual analog scale (P = 0.03). In eRA, IgG2 against P. gingivalis was associated with ESR (P = 0.046) and ACPAs (P = 0.04). P. gingivalis was associated with ACPAs (P = 0.04). This study shows that individuals with pre‐RA have significant inflammatory periodontal involvement. There was a significant association between IgG against P. gingivalis and ACPAs in pre‐RA and markers of RA activity in individuals with eRA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1902/jop.2015.150455
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1943-3670
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5133
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalJournal of Periodontologyspa
dc.relation.ispartofseriesJournal of Periodontology, 1943-3670, Vol. 87, No. 4, 2016, p. 346-356spa
dc.relation.urihttps://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2015.150455
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-04
dc.rights.localAcceso abiertospa
dc.subject.keywordsArthritisspa
dc.subject.keywordsRheumatoidspa
dc.subject.keywordsAutoantibodiesspa
dc.subject.keywordsCyclic citrullinated peptidespa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsPorphyromonas gingivalisspa
dc.subject.keywordsRheumatoid factorspa
dc.titlePeriodontal disease in individuals with a genetic risk of developing arthritis and early rheumatoid arthritis: A cross-sectional studyspa
dc.title.translatedPeriodontal disease in individuals with a genetic risk of developing arthritis and early rheumatoid arthritis: A cross-sectional studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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