Association of daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a review

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dc.contributor.authorFoolad, Farnaz
dc.contributor.authorTaylor, Brandie D
dc.contributor.authorShelburne, Samuel A
dc.contributor.authorArias, Cesar A.
dc.contributor.authorAitken, Samuel
dc.date.accessioned2020-05-15T17:45:26Z
dc.date.available2020-05-15T17:45:26Z
dc.date.issued2018
dc.description.abstractenglishVRE are associated with ∼1300 deaths per year in the USA. Recent literature suggests that daptomycin, a cyclic lipopeptide antibiotic with concentration-dependent bactericidal activity, is the preferred treatment option for VRE bacteraemia, yet the optimal dosing strategy for this indication has not been established. In vitro evidence suggests that higher-than-labelled doses of daptomycin are required to optimally treat VRE bacteraemia and to inhibit the development of resistance. However, concern of dose-dependent toxicities, notably increases in creatine phosphokinase and the development of rhabdomyolysis, are a barrier to initiating high-dose schemes in clinical practice. Thus, the effectiveness and safety of high-dose daptomycin regimens in clinical practice have remained unclear. While early studies failed to identify differences in mortality, newer, larger investigations suggest high-dose (≥9 mg/kg) daptomycin is associated with reduced mortality in patients with VRE bacteraemia compared with standard (6 mg/kg) dosing regimens. Additionally, the high-dose regimens appear to be safe and may be associated with improved microbiological outcomes. The purpose of this review is to examine the published evidence on the effectiveness and safety of high-dose daptomycin compared with standard dosing regimens for VRE bacteraemia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/jac/dky072
dc.identifier.issn1460-2091
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2841
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalJournal of Antimicrobial Chemotherapyspa
dc.relation.ispartofseriesJournal of Antimicrobial Chemotherapy, 1460-2091, Vol 73, Num 9, 2018, pag 2277–2283spa
dc.relation.urihttps://academic.oup.com/jac/article/73/9/2277/4934159
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsEnterococcusspa
dc.subject.decsInfeccionesspa
dc.subject.decsMortalidadspa
dc.subject.keywordsBacteremiaspa
dc.subject.keywordsDaptomycinspa
dc.subject.keywordsMortalityspa
dc.titleAssociation of daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a reviewspa
dc.title.translatedAssociation of daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a reviewspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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