Adding nebulized corticosteroids to systemic corticosteroids for acute asthma in children: a systematic review with meta-analysis

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dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorPincheira, Mauricio A.
dc.contributor.authorEscobar-Serna, Diana Paola
dc.contributor.authorSossa-Briceño, Mónica P.
dc.date.accessioned2020-08-19T22:13:28Z
dc.date.available2020-08-19T22:13:28Z
dc.date.issued2020
dc.description.abstractenglishAbstract International guidelines have recommended the use of inhaled beta‐2 agonists and systemic corticosteroids (SCs) as the first‐line treatment for acute asthma. Objective To evaluate the evidence for the efficacy of inhaled corticosteroids (ICSs) in addition to SCs compared to SCs alone in children with acute asthma in the emergency department (ED) or during hospitalization. Data Sources Five electronic databases were searched. Study Selection All randomized clinical trials that compared ICS (via nebulizer or metered dose inhaler) plus SC (oral or parenteral) with placebo (or standard care) plus SC were included without language restriction. Data Extraction Two reviewers independently reviewed all the studies. The primary outcomes were hospital admission and hospital length of stay (LOS), and secondary outcomes were readmissions during follow‐up, ED‐LOS, lung function, asthma clinical score, oxygen saturation, and heart and respiratory rates. Results Nine studies (n = 1473) met the inclusion criteria. In all the studies, the ICS was budesonide. Compared to SC alone, adding budesonide to SC did not affect hospitalization rate, but decreased hospital LOS by more than 1 day (MD = −29.08 hours [−39.9 to −18.3]; I2 = 0%, P = < .00001). Moreover, adding budesonide significantly improved the acute asthma severity score among patients at ED. Conclusions Compared to SC alone, adding budesonide to SC does not affect the hospitalization rate, but decreases the LOS and improves the acute asthma score in children in an ED setting.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/ppul.24956
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1099-0496
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3816
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc.spa
dc.publisher.journalPediatric pulmonologyspa
dc.relation.ispartofseriesPediatric pulmonology, 1099-0496, 2020spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24956
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.creativecommons2020-07-13
dc.rights.localAcceso abiertospa
dc.subject.keywordsAcute asthmaspa
dc.subject.keywordsNebulizedspa
dc.subject.keywordsSystemic corticosteroidsspa
dc.titleAdding nebulized corticosteroids to systemic corticosteroids for acute asthma in children: a systematic review with meta-analysisspa
dc.title.translatedAdding nebulized corticosteroids to systemic corticosteroids for acute asthma in children: a systematic review with meta-analysisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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