Impact of COVID-19 infection on patients with Cancer: experience in a Latin American Country: The ACHOCC-19 Study

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dc.contributor.authorOspina, Aylen Vanessa
dc.contributor.authorBrugues, Ricardo
dc.contributor.authorMantilla, William
dc.contributor.authorTriana, Iván
dc.contributor.authorRamos, Pedro
dc.contributor.authorAruachan, Sandra
dc.contributor.authorQuiroga, Alicia
dc.contributor.authorMunevar, Isabel
dc.contributor.authorOrtiz, Juan
dc.contributor.authorLlinás, Néstor
dc.contributor.authorPinilla, Paola
dc.contributor.authorVargas, Henry
dc.contributor.authorIdrobo, Henry
dc.contributor.authorRussi, Andrea
dc.contributor.authorManneh Kopp, Ray
dc.contributor.authorRivas, Giovanna
dc.contributor.authorGonzález, Héctor
dc.contributor.authorSanta, Daniel
dc.contributor.authorInsuasty, Jesús
dc.contributor.authorBernal, Laura
dc.contributor.authorOtero, Jorge
dc.contributor.authorVargas, Carlos
dc.contributor.authorPacheco, Javier
dc.contributor.authorAlcalá, Carmen
dc.contributor.authorJiménez, Paola
dc.contributor.authorLombana, Milton
dc.contributor.authorContreras, Fernando
dc.contributor.authorSegovia, Javier
dc.contributor.authorPino, Luis
dc.contributor.authorLobatón, José
dc.contributor.authorGonzález, Manuel
dc.contributor.authorCuello, Javier
dc.contributor.authorBogoya, Juliana
dc.contributor.authorBarrero, Angela
dc.contributor.authorde Lima Lopes Jr, Gilberto
dc.date.accessioned2022-02-15T14:40:20Z
dc.date.available2022-02-15T14:40:20Z
dc.date.issued2021
dc.description.abstractenglishIntroduction The ACHOCC-19 study was performed to characterize COVID-19 infection in a Colombian oncological population. Methodology Analytical cohort study of patients with cancer and COVID-19 infection in Colombia. From April 1 to October 31, 2020. Demographic and clinical variables related to cancer and COVID-19 infection were collected. The primary outcome was 30-day mortality from all causes. The association between the outcome and the prognostic variables was analyzed using logistic regression models and survival analysis with Cox regression. Results The study included 742 patients; 72% were >51 years. The most prevalent neoplasms were breast (132, 17.77%), colorectal (92, 12.34%), and prostate (81, 10.9%). Two hundred twenty (29.6%) patients were asymptomatic and 96 (26.3%) died. In the bivariate descriptive analysis, higher mortality occurred in patients who were >70 years, patients with lung cancer, ≥2 comorbidities, former smokers, receiving antibiotics, corticosteroids, and anticoagulants, residents of rural areas, low socioeconomic status, and increased acute-phase reactants. In the logistic regression analysis, higher mortality was associated with Eastern Cooperative Oncology Group performance status (ECOG PS) 3 (odds ratio [OR] 28.67; 95% confidence interval [CI], 8.2–99.6); ECOG PS 4 (OR 20.89; 95% CI, 3.36–129.7); two complications from COVID-19 (OR 5.3; 95% CI, 1.50–18.1); and cancer in progression (OR 2.08; 95% CI, 1.01–4.27). In the Cox regression analysis, the statistically significant hazard ratios (HR) were metastatic disease (HR 1.58; 95% CI, 1.16–2.16), cancer in progression (HR 1.08; 95% CI, 1.24–2.61) cancer in partial response (HR 0.31; 95% CI, 0.11–0.88), use of steroids (HR 1.44; 95% CI, 1.01–2.06), and use of antibiotics (HR 2.11; 95% CI, 1.47–2.95). Conclusion In our study, patients with cancer have higher mortality due to COVID-19 infection if they have active cancer, metastatic or progressive cancer, ECOG PS >2, and low socioeconomic status. Implications for Practice This study's findings raise the need to carefully evaluate patients with metastatic cancer, in progression, and with impaired Eastern Cooperative Oncology Group status to define the relevance of cancer treatment during the pandemic, consider the risk/benefit of the interventions, and establish clear and complete communication with the patients and their families about the risk of complications. There is also the importance of offering additional support to patients with low income and residence in rural areas so that they can have more support during cancer treatment.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/onco.13861
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1549-490X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/6845
dc.language.isospa
dc.publisherWileyspa
dc.publisher.journalThe Oncologistspa
dc.relation.ispartofseriesThe Oncologist, 1549-490X, Vol. 26, 2021, p. 1–13spa
dc.relation.urihttps://theoncologist.onlinelibrary.wiley.com/doi/10.1002/onco.13861
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.keywordsCOVID-19spa
dc.subject.keywordsCancerspa
dc.subject.keywordsSurvival Mortalityspa
dc.subject.keywordsLatin American country Colombiaspa
dc.titleImpact of COVID-19 infection on patients with Cancer: experience in a Latin American Country: The ACHOCC-19 Studyspa
dc.title.translatedImpact of COVID-19 infection on patients with Cancer: experience in a Latin American Country: The ACHOCC-19 Studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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