Principal findings of systematic reviews for chronic treatment in childhood asthma

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dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorRodrigo, Gustavo J.
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.date.accessioned2020-08-13T19:33:15Z
dc.date.available2020-08-13T19:33:15Z
dc.date.issued2015
dc.description.abstractenglishObjective: To summarize the principal findings pertaining to most effective long-term pharmacologic treatment of childhood asthma. Methods: Systematic reviews of randomized clinical trials (SRCTs) on pharmacologic chronic treatment in children (1–18 years) with persistent asthma were retrieved through MEDLINE, EMBASE, CINAHL, SCOPUS, and CDSR (up to January2014). Results: One hundred eighty-three SRCTs were searched from databases. Among those, 39 SRCTs were included: two were related to step 1, 24 to step 2, nine to steps 3 and 4, and four to step 5 (according with NAEPP and GINA guidelines). The methodological quality of these SRCTs was determined by using the AMSTAR tool. Results: For step 1: addition of ipatropium bromide to short-acting beta2-agonists does not show any benefit. For step 2: in preschoolers, inhaled corticosteroids (ICSs) reduce severe exacerbations and improve other clinical and lung function parameters. In children, ICSs are superior to leukotriene receptor antagonist (LTRA), cromones, or xantines in reducing severe exacerbations, improving lung function and other clinical outcomes. Fluticasone propionate (FP) is better than beclomethasone dipropionate (BDP) or budesonide only for lung function; but similar to hydrofluoroalkane-BDP or to ciclosenide. Compared to low ICSs doses, moderate doses result in only better lung function, but this is not true for FP. For steps 3 and 4: adding LTRA to ICS confers a small benefit; adding LABA improves lung function but does not reduce exacerbations more than double or higher ICS doses. For step 5: adding omalizumab decreases exacerbations. Conclusions: SRCTs are useful for guiding decisions in chronic childhood asthma treatment.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3109/02770903.2014.971968
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1532-4303
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3783
dc.language.isoeng
dc.publisherTaylor and Francisspa
dc.publisher.journalJournal of Asthmaspa
dc.relation.ispartofseriesJournal of Asthma, 1532-4303, Vol. 52, Nro. 4, 2015, p. 407-416spa
dc.relation.urihttps://www.tandfonline.com/doi/full/10.3109/02770903.2014.971968
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2014-10-29
dc.rights.localAcceso abiertospa
dc.subject.keywordsAdolescentspa
dc.subject.keywordsAMSTARspa
dc.subject.keywordsChildrenspa
dc.subject.keywordsChronic asthma managementspa
dc.subject.keywordsMeta-analysisspa
dc.subject.keywordsSystematic reviewspa
dc.subject.keywordsTreatmentspa
dc.titlePrincipal findings of systematic reviews for chronic treatment in childhood asthmaspa
dc.title.translatedPrincipal findings of systematic reviews for chronic treatment in childhood asthmaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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