Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia

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dc.contributor.authorNino, Gustavo
dc.contributor.authorMansoor, Awais
dc.contributor.authorPerez, Geovanny
dc.contributor.authorArroyo, Maria
dc.contributor.authorXu Chen, Xilei
dc.contributor.authorWeinstock, Jered
dc.contributor.authorSalka, Kyle
dc.contributor.authorSaid, Mariam
dc.contributor.authorAcuña-Cordero, Ranniery
dc.contributor.authorSossa-Briceño, Monica P.
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.contributor.authorLinguraru, Marius George
dc.date.accessioned2020-02-11T19:03:26Z
dc.date.available2020-02-11T19:03:26Z
dc.date.issued2020
dc.description.abstractenglishWe need a better risk stratifcation system for the increasing number of survivors of extreme prematurity sufering the most severe forms of bronchopulmonary dysplasia (BPD). However, there is still a paucity of studies providing scientifc evidence to guide future updates of BPD severity defnitions. Our goal was to validate a new predictive model for BPD severity that incorporates respiratory assessments beyond 36 weeks postmenstrual age (PMA). We hypothesized that this approach improves BPD risk assessment, particularly in extremely premature infants. This is a longitudinal cohort of premature infants (≤32 weeks PMA, n=188; Washington D.C). We performed receiver operating characteristic analysis to defne optimal BPD severity levels using the duration of supplementary O2 as predictor and respiratory hospitalization after discharge as outcome. Internal validation included lung X-ray imaging and phenotypical characterization of BPD severity levels. External validation was conducted in an independent longitudinal cohort of premature infants (≤36 weeks PMA, n=130; Bogota). We found that incorporating the total number of days requiring O2 (without restricting at 36 weeks PMA) improved the prediction of respiratory outcomes according to BPD severity. In addition, we defned a new severity category (level IV) with prolonged exposure to supplemental O2 (≥120 days) that has the highest risk of respiratory hospitalizations after discharge. We confrmed these fndings in our validation cohort using ambulatory determination of O2 requirements. In conclusion, a new predictive model for BPD severity that incorporates respiratory assessments beyond 36 weeks improves risk stratifcation and should be considered when updating current BPD severity defnitions.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41598-019-56355-5
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2045-2322
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1928
dc.language.isoeng
dc.publisherNature Publishing Groupspa
dc.publisher.journalScientific Reportsspa
dc.relation.ispartofseriesScientific Reports, 2045-2322, 2020, p. 1-10spa
dc.relation.urihttps://www.nature.com/articles/s41598-019-56355-5
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf379
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsRecien nacido prematurospa
dc.subject.decsEnfermedades del recién nacidospa
dc.subject.decsDisplasia broncopulmonarspa
dc.subject.decsRiesgo a la saludspa
dc.titleValidation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasiaspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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