Pseudomonas aeruginosa coharboring BlaKPC-2 and BlaVIM-2 carbapenemase Genes

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dc.contributor.authorPacheco P., Tatiana
dc.contributor.authorBustos Cruz, Rosa Helena
dc.contributor.authorAbril Riaño, Deisy Julieth
dc.contributor.authorArias V., Sara
dc.contributor.authorUribe, Lina
dc.contributor.authorRincón, Jenny
dc.contributor.authorGarcía C., Julio César
dc.contributor.authorEscobar-Pérez, Javier
dc.contributor.orcidEscobar-Pérez, Javier [0000-0002-0432-6978]
dc.contributor.orcidAbril Riaño, Deisy Julieth [0000-0002-6686-6283]
dc.date.accessioned2019-09-13T13:07:30Z
dc.date.available2019-09-13T13:07:30Z
dc.date.issued2019
dc.description.abstractenglishPseudomonas aeruginosa, a bacterium commonly isolated from hospital settings, exhibits intrinsic resistance to a number of antibiotics and can acquire resistance during antibiotic therapy. Resistance towards carbapenems is increasing due to its overuse in the treatment of infections caused by extended-spectrum β-lactamase (ESBL) producing organisms. Nonetheless, carbapenems are essential for the treatment of high-risk infections and are one of the remaining weapons in the fight against “extreme drug resistance” of Gram-negative/positive bacilli. Herein, we describe a case report of infections caused by P. aeruginosa strains that carry blaVIM-2 and blaKPC-2 carbapenemase genes simultaneously, identified in five patients who were admitted to a high complexity health institution in Colombia. Molecular characterization included PCR screening for blaKPC, blaGES, blaOXA-48, blaIMP, blaNDM, and blaVIM carbapenemase and other resistance genes as well as analysis of the genetic relationships by genome macro-restriction and Pulsed-Field Gel Electrophoresis (PFGE) separation. In conclusion, these infections represent a major challenge to public health due to the risk of the infection spreading compounded by the fact that limited treatment options are available, thereby increasing the risk of increased morbidity and mortality.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/antibiotics8030098
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2079-6382
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1677
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing institutespa
dc.publisher.journalAntibioticsspa
dc.relation.ispartofseriesAntibiotics, 2079-6382, Vol. 8, Nro. 3, 2019, p. 1-10spa
dc.relation.urihttps://www.mdpi.com/2079-6382/8/3/98
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf245
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsInfección hospitalariaspa
dc.subject.decsResistencia a medicamentosspa
dc.subject.decsEnterobacteriaceaespa
dc.subject.keywordsPseudomonas aeruginosaspa
dc.subject.keywordsCarbapenemsspa
dc.subject.keywordsVerona Integron-encoded metallo-β-lactamasespa
dc.titlePseudomonas aeruginosa coharboring BlaKPC-2 and BlaVIM-2 carbapenemase Genesspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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