Native valve endocarditis caused by corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?

Cargando...
Miniatura

Fecha

2012

Título de la revista

Publicado en

Antimicrobial agents and chemotherapy, 1098-6596, Vol. 56, Nro. 6, 2012, p. 3461-3464

Publicado por

American Society for Microbiology

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.

Palabras clave

Keywords

Temáticas

Cefotaxima
Staphylococcus aureus resistente a la meticilina
Antibacterianos

Citación

Colecciones