Comparison of the bronchodilating effects of albuterol delivered by valved vs. non-valved spacers in pediatric asthma

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dc.contributor.authorRodriguez‐Martinez, Carlos E.
dc.contributor.authorSossa‐Briceño, Mónica P.
dc.contributor.authorCastro‐Rodriguez, Jose A.
dc.date.accessioned2020-08-31T09:49:21Z
dc.date.available2020-08-31T09:49:21Z
dc.date.issued2012
dc.description.abstractenglishInhaled therapy using a metered‐dose inhaler (MDI ) with attached valved holding chamber has been increasingly recognized as the optimal method for delivering bronchodilators for asthma treatment. However, mainly due to the high cost of these valved holding chambers in many developing countries, the use of non‐valved spacers is frequent, despite the scarce evidence that supports their efficacy. The aim of this study was to compare the bronchodilator response to albuterol administered by MDI with and without a valved spacer. In a randomized, two‐period, two‐sequence crossover clinical trial, we analyzed 31 stable asthmatic children (6–18 yrs of age) on two consecutive days, who were randomly assigned to receive 100 μg of albuterol MDI through either a locally produced valved spacer or a non‐valved spacer. The next day, a crossover treatment was employed through the use of the other spacer. Spirometry was recorded before and after each albuterol administration. As we were not able to identify any sequence or carryover effect, we tested for treatment effects in both periods. No significant differences in the absolute change in FEV 1 (0.20 ± 0.17 vs. 0.18 ± 0.16, p = 0.63), FVC (0.07 ± 0.13 vs. 0.07 ± 0.16, p = 0.88), or MMEF (0.49 ± 0.31 vs. 0.43 ± 0.39, p = 0.53) after bronchodilator administration were found between the use of valved and non‐valved spacers. In stable asthmatic children, albuterol administered through MDI using a non‐valved spacer produces a bronchodilator response similar to that of a spacer with a valve that requires an inhalatory opening pressure (with flows between 2 and 32 l/min) that even toddlers with bronchial obstruction can easily generate.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/pai.12008
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0905-6157
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3884
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalPediatric Allergy and Immunologyspa
dc.relation.ispartofseriesPediatric Allergy and Immunology, 0905-6157, Vol. 23, No. 7, 2012 p. 629-635spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/pai.12008
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2012-11
dc.rights.localAcceso abiertospa
dc.subject.decsAsmaspa
dc.subject.decsEnfermedades bronquialesspa
dc.subject.decsPediatríaspa
dc.subject.keywordsAsthmaspa
dc.subject.keywordsPediatricsspa
dc.subject.keywordsTherapeuticsspa
dc.subject.keywordsInhalationspa
dc.subject.keywordsSpacersspa
dc.titleComparison of the bronchodilating effects of albuterol delivered by valved vs. non-valved spacers in pediatric asthmaspa
dc.title.translatedComparison of the bronchodilating effects of albuterol delivered by valved vs. non-valved spacers in pediatric asthmaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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