Preclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin wound

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dc.contributor.authorMillán, Diana
dc.contributor.authorJimenez, Ronald
dc.contributor.authorNieto, L. E.
dc.contributor.authorLinero, Itali M.
dc.contributor.authorLaverde, M.
dc.contributor.authorFontanilla, Marta Raquel
dc.date.accessioned2020-07-16T16:13:26Z
dc.date.available2020-07-16T16:13:26Z
dc.date.issued2016
dc.description.abstractenglishPreviously, we have developed collagen type I scaffolds including microparticles of gelatin-collagen type I (SGC) that are able to control the release of a hydroglycolic extract of the Calendula officinalis flower. The main goal of the present work was to carry out the preclinical evaluation of SGC alone or loaded with the C. officinalis extract (SGC-E) in a lagomorph model of full-thickness skin wound. A total of 39 rabbits were distributed in three groups, of 13 animals each. The first group was used to compare wound healing by secondary intention (control) with wound healing observed when wounds were grafted with SGC alone. Comparison of control wounds with wounds grafted with SGC-E was performed in the second group, and comparison of wounds grafted with SGC with wounds grafted with SGC-E was performed in the third group. Clinical follow-ups were carried in all animals after surgery, and histological and histomorphometric analyses were performed on tissues taken from the healed area and healthy surrounding tissue. Histological and histomorphometric results indicate that grafting of SGC alone favors wound healing and brings a better clinical outcome than grafting SGC-E. In vitro collagenase digestion data suggested that the association of the C. officinalis extract to SGC increased the SGC-E cross-linking, making it difficult to degrade and affecting its biocompatibility.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1007/s13346-015-0265-8
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2190-3948
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3535
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalDrug delivery and translational researchspa
dc.relation.ispartofseriesDrug delivery and translational research, 2190-3948, Vol. 6, Nro. 1, 2016, p. 57-66spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs13346-015-0265-8
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-02-01
dc.rights.localAcceso abiertospa
dc.subject.decsColágeno tipo Ispa
dc.subject.decsCopolímero de ácido poliláctico-ácido poliglicólicospa
dc.subject.decsPlantas medicinalesspa
dc.subject.keywordsCollagen type Ispa
dc.subject.keywordsScaffoldsspa
dc.subject.keywordsGelatin-collagenmicroparticlesspa
dc.titlePreclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin woundspa
dc.title.translatedPreclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin woundspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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