Analysis of in vitro osteoblast culture on scaffolds for future bone regeneration purposes in dentistry

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dc.contributor.authorGutiérrez-Prieto, Sandra J.
dc.contributor.authorPerdomo Lara, Sandra Janneth
dc.contributor.authorDíaz-Peraza, José M.
dc.contributor.authorSequeda-Castañeda, Luis Gonzalo
dc.contributor.orcidPerdomo Lara, Sandra Janneth [0000-0002-4429-3760]
dc.date.accessioned2019-07-02T15:42:35Z
dc.date.available2019-07-02T15:42:35Z
dc.date.issued2019
dc.description.abstractenglishOne of the main focuses of tissue engineering is to search for tridimensional scaffold materials, complying with nature’s properties for tissue regeneration. Determining material biocompatibility is a fundamental step in considering its use. Therefore, the purpose of this study was to analyze osteoblast cell adhesion and viability on different materials to determine which was more compatible for future bone regeneration. Tridimensional structures were fabricated with hydroxyapatite, collagen, and porous silica. The bovine bone was used as material control. Biocompatibility was determined by seeding primary osteoblasts on each tridimensional structure. Cellular morphology was assessed by SEM and viability through confocal microscopy. Osteoblast colonization was observed on all evaluated materials’ surface, revealing they did not elicit osteoblast cytotoxicity. Analyses of four different materials studied with diverse compositions and characteristics showed that adhesiveness was best seen for HA and viability for collagen. In general, the results of this investigation suggest these materials can be used in combination, as scaffolds intended for bone regeneration in dental and medical fields.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2019/5420752
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1687-6342
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1473
dc.language.isoeng
dc.publisherHindawispa
dc.publisher.journalAdvances in Pharmacological Sciencesspa
dc.relation.ispartofseriesAdvances in Pharmacological Sciences, 1687-6342, 2019, 9 p.spa
dc.relation.urihttps://www.hindawi.com/journals/aps/2019/5420752/
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf165
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsOsteoblastosspa
dc.subject.decsRegeneración óseaspa
dc.subject.decsTécnicas de cultivo de tejidosspa
dc.titleAnalysis of in vitro osteoblast culture on scaffolds for future bone regeneration purposes in dentistryspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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