Critical-sized mandibular defect reconstruction using human dental pulp stem cells in a xenograft model-clinical, radiological, and histological evaluation

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dc.contributor.authorGutiérrez-Quintero, Juan G.
dc.contributor.authorDurán Riveros, Juan Y.
dc.contributor.authorMartínez Valbuena, Carlos A.
dc.contributor.authorPedraza Alonso, Sofía
dc.contributor.authorMunévar Niño, Juan Carlos
dc.contributor.authorViafara García, Sergio Marino
dc.contributor.orcidViafara García, Sergio Marino [0000-0002-4208-1422]
dc.contributor.orcidMunévar Niño, Juan Carlos [0000-0002-8482-2962]
dc.date.accessioned2020-07-21T20:34:30Z
dc.date.available2020-07-21T20:34:30Z
dc.date.issued2020
dc.description.abstractenglishPurpose: This research evaluated clinical, histological, and radiological osseous regeneration in a critical-sized bilateral cortico-medullary osseous defect in model rabbits from New Zealand after receiving a hydroxyapatite matrix and polylactic polyglycolic acid (HA/PLGA) implanted with human dental pulp stem cells (DPSCs). Methods: Eight New Zealand rabbits with bilateral mandibular critical-sized defects were performed where one side was treated with an HA/PLGA/DPSC matrix and the other side only with an HA/PLGA matrix for 4 weeks. Results: An osseointegration was clinically observed as well as a reduction of 70% of the surgical lumen on one side and a 35% on the other. Histologically, there was neo-bone formation in HA/PLGA/DPSC scaffold and angiogenesis. A bone radiodensity (RD) of 80% was radiologically observed achieving density levels similar to mandibular bone, while the treatment with HA/PLGA matrix achieves RD levels of 40% on its highest peaks. Conclusions: HA/PLGA/DPSC scaffold was an effective in vivo method for mandibular bone regeneration in critical-sized defects induced on rabbit models.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s10006-020-00862-7
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1865-1569
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3561
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalOral and maxillofacial surgeryspa
dc.relation.ispartofseriesOral and maxillofacial surgery, 1865-1569, 2020spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs10006-020-00862-7
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.subject.decsMedicina regenerativaspa
dc.subject.decsAndamios del tejidospa
dc.subject.decsHuesos facialesspa
dc.subject.keywordsBone regenerationspa
dc.subject.keywordsMesenchymal stem cellsspa
dc.subject.keywordsXenograftspa
dc.titleCritical-sized mandibular defect reconstruction using human dental pulp stem cells in a xenograft model-clinical, radiological, and histological evaluationspa
dc.title.translatedCritical-sized mandibular defect reconstruction using human dental pulp stem cells in a xenograft model-clinical, radiological, and histological evaluationspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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